Neonatal sepsis disease progressed rapidly.Acute kidney injury(AKI) and diffuse intravascular coagulation(DIC)were common organ dysfunction.It should be early screened to avoid aggravation of organ function damage and lifethreatening. Adequate fluid resuscitation was the key to reversal of tissue hypoperfusion in sepsis. The paper reported a case of neonatal sepsis with AKI and DIC. After hospitalization, the baby were performed with several boluses of saline for rapid restoration of the circulating intrava...