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聚乙二醇修饰氧化钨纳米探针的合成及用于胃肠道CT成像

Facile Synthesis of PEGylated Tungsten-based Nanoprobes for Gastric Computed Tomography Imaging

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【作者】 张天琪韩雪立何洋洋何晓静王建秋袁庆海刘建华

【Author】 ZHANG Tian-Qi;HAN Xue-Li;HE Yang-Yang;HE Xiao-Jing;WANG Jian-Qiu;YUAN Qing-Hai;LIU Jian-Hua;Department of Radiology,the Second Hospital of Jilin University;Department of Pathology,the Second Hospital of Jilin University;Department of Radiology,the Second Hospital of Chongqing Medical University;State Key Laboratory of Inorganic Synthesis and Preparative Chemistry,College of Chemistry,Jilin University;

【通讯作者】 袁庆海;刘建华;

【机构】 吉林大学第二医院放射线科吉林大学第二医院病理科重庆医科大学附属第二院放射线科吉林大学化学学院无机合成与制备国家重点实验室

【摘要】 随着现代医学以及纳米科技的发展,聚乙二醇修饰的纳米探针在分子成像领域引起了广泛关注,在胃肠道疾病的诊断和预后中发挥了重要作用。本研究构建了基于过渡金属氧化物的聚乙二醇修饰氧化钨纳米探针(PEG-WO3-x),用于胃肠道疾病CT成像分析。首先通过高温溶剂热方法合成氧化钨纳米探针,用聚乙二醇修饰以提高其在水中的分散性及稳定性。采用扫描电子显微镜(SEM)、透射电子显微镜(TEM)、X-射线光电子能谱(XPS)和红外光谱等对合成的PEG-WO3-x进行了表征,通过组织病理学方法评价其在大鼠体内的毒性。结果表明,PEG-WO3-x具有较低的体内毒性。考察了PEG-WO3-x体外以及大鼠体内的螺旋CT成像效果,结果表明,PEG-WO3-x具有良好的胃肠道CT成像能力。PEG-WO3-x在螺旋CT对胃肠道疾病的诊断中具有良好的应用前景。

【Abstract】 Polyethyleneglycol( PEG)-modified( PEGylated) nanoprobes have attracted a great deal of interest in the area of molecular imaging area along with the rapid development of modern medicine. These nanoprobes play an important role especially in the diagnosis and prognosis of gastric diseases. The transition metal oxides as gastric contrast agents based on PEGylated WO3-x nanoprobes( PEG-WO3-x) were designed and synthesized. The nanoprobes ewere synthesized via a high-temperature solvent thermal method,and then modified with PEG. These PEGylated nanoprobes exhibited excellent aqueous stability. Besides evaluating the characteristics of PEG-WO3-x,in vivo,toxicological studies were carried out with histopathology. Otherwise,as a contrast agent,MDCT imaging was illustrated via both in vitro and in vivo assessment. The experimental results indicated that the prepared PEG-WO3-x showed great potential for further MDCT imaging in detection of gastric diseases.

【基金】 国家自然科学基金项目(No.81571737);吉林省科技厅自然基金项目(No.20180101119JC);吉林省卫计委青年基金项目(No.2017Q012);吉林省财政厅卫生专项基金项目(No.20180029);重庆市卫计委医学科研计划项目(No.2016MSXM024)资助~~
  • 【文献出处】 分析化学 ,Chinese Journal of Analytical Chemistry , 编辑部邮箱 ,2018年10期
  • 【分类号】O657.3;R816.5
  • 【被引频次】1
  • 【下载频次】226
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