【摘要】 转化生长因子-β1(TGF-β1)在肺纤维化发展过程中介导复杂的促进纤维化信号通路,特别是在肺组织的损伤修复中,TGF-β1作为重要的细胞生长因子起到重要作用,它可激活成纤维细胞,促进基质合成,产生大量胶原蛋白。放射性肺损伤是在肺部疾病的放射治疗中常见的并发症,早期表现为放射性肺炎,晚期表现为放射性肺纤维化。了解和掌握TGF-β1在肺纤维化的发生、发展中的分子机制,对防治肺纤维化,减少并发症的发生具有重要意义。本文对TGF-β1在放射性肺纤维化中作用的分子机制及治疗进展进行综述。更多还原

【Abstract】 Transforming growth factor-β1( TGF-β1) mediates complex fibrotic signaling pathways during the development of pulmonary fibrosis. Especially in the repair of lung tissue injury,TGF-β1,as an important cell growth factor plays an important role,can activate fibroblasts and promote matrix synthesis,resulting in a large number of collagen. Radiation induced lung injury is a common complication in radiotherapy of lung disease. Early manifestations are radioactive pneumonia and advanced manifestations are radioactive pulmonary fibrosis. Understanding of the molecular mechanism of TGF-β1 in the pathogenesis and progression of pulmonary fibrosis is of great significance to prevent,treat pulmonary fibrosis and reduce the incidence of complications. In this paper,the molecular mechanism of TGF-β1 in the role of radiation pulmonary fibrosis and treatment progress were reviewed.更多还原