【摘要】 目的:总结并比较儿童典型失神(TAS)发作和不典型失神(AAS)发作的临床特点、治疗及预后。方法:收集失神发作性癫痫患儿临床资料37例,其中TAS组19例,AAS组18例,并进行随访。结果:TAS组起病年龄3. 7～10. 2岁,4～10岁起病17例,占89. 5%,无神经系统发育及头颅影像学检查异常,有特征性脑电图改变,治疗完全控制率为83. 3%。AAS组66. 7%合并其他发作形式,神经系统发育及头颅影像学检查异常分别为55. 6%和43. 8%,脑电图改变多样,治疗完全控制率为33. 3%。两组治疗完全控制率比较差异有统计学意义(P<0. 05)。结论:TAS起病与年龄相关,多无神经系统发育及检查异常,且有特征性的脑电图改变,预后良好; AAS发病年龄差异大,多有神经系统发育及检查异常,预后较差。更多还原

【Abstract】 Objective: To summarize and compare the clinical features,treatment and prognosis of children with typical absence seizure( TAS) and atypical absence seizure( AAS). Methods: A case-based follow-up survey was conducted in 37 children with absence seizures,including 19 cases of TAS and 18 cases of AAS. Results: The onset-age of TAS group was 3.7 ～ 10.2 years old,and 17 cases started from 4 ～ 10 years old,accounting for 89.5%. There was no abnormality in nervous system development and cranial imaging examination,and there were characteristic EEG changes,the complete control rate was 83. 3%. A total of 66. 7% of the AAS group combined with other seizures,abnormalities in nervous system development and cranial imaging examination were 55.6% and 43. 8%,respectively. The EEG was varied,and the complete control rate was 33. 3%. The difference between two groups was statistically significant( P<0.05). Conclusion: The onset of TAS is age-related,which has no abnormalities in nervous system development and cranial imaging examination,and characteristic EEG changes with good prognosis. The onset-age of AAS varied greatly and there were mostly abnormal nervous system development and examination,the prognosis was relatively poor.更多还原