【摘要】 目的了解维生素D缺乏与变应性鼻炎(AR)的关系及对AR患者生活质量的影响。方法 28例对照组选取于2013年5～12月湖南省人民医院体检中心健康体检者,同时选取耳鼻咽喉科门诊62例变应性鼻炎患者作为实验组,分为轻度持续性AR(persistent AR,PAR)组30例及中重度PAR组32例。所有研究对象均抽取静脉血检测25羟基维生素D[25(OH)D],实验组在随访中完成鼻结膜炎相关生活质量问卷(rhinoconjunctivitis quality of life questionnaire,RQLQ)评分。比较三组中维生素D缺乏的发生率以及维生素D缺乏对两组AR患者RQLQ评分的影响。结果维生素D缺乏发生率比较,中重度PAR组及轻度PAR组均高于对照组,差异具有显著性(χ~2=25.16、16.84,P均<0.01),但中重度PAR组与轻度PAR组比较差异无统计学意义(χ~2=4.37,P>0.05);中重度PAR组及轻度PAR组的25(OH)D水平与RQLQ评分呈负相关(r=-0.643、-0.519,P均<0.01),两组间的RQLQ评分差异有统计学意义(χ~2=1.454,P<0.05)。结论维生素D缺乏在AR患者中发生率较高,可能与AR有一定的相关性,并对AR患者的生活质量有负面影响。更多还原

【Abstract】 OBJECTIVE To observe the incidence of vitamin D deficiency in patients with allergic rhinitis(AR)and to study the impact of vitamin D deficiency on the quality of life in AR patients. METHODS Twenty eight healthy subjects(control group) from Physical Examination Center in Hunan Provincial People’s Hospital from May2013 to Dec 2013 were enrolled in this study. Meanwhile62 AR patients chosen form outpatient department were divided into persistent moderate/severe AR group(32 cases) and persistent mild AR group(30 cases) according to ARIA(allergic rhinitis and its impact on asthma). All subjects in three groups signed informed consent and were collected venous blood from elbow. The 62 AR patients finished the RQLQ through telephone follow-up. Finally,the incidence of vitamin D deficiency were calculated and compared among three groups. The relationship between 25(OH)D and RQLQ scores, grading RQLQ of AR patients, the scores between mild group and moderate/severe group were analyzed. RESULTS The incidence of vitamin D deficiency in the moderate/severe AR group and mild AR was significantly higher than that in the control group(χ~2=25.16, 16.84, P <0.05), though there was no significant difference between the moderate/severe AR group and the mild AR group(χ~2=4.37, P>0.05). The 25(OH)D levels in the moderate/severe AR group and the mild AR group were negatively correlated with RQLQ scores(r =-0.643,-0.519, P<0.01). Significant difference was found between the moderate/severe AR group and the mild AR group in RQLQ scores( χ~2=1.454, P<0.01).CONCLUSION The incidence of vitamin D deficiency in AR patients is higher, which may imply there are some relevance and vitamin D deficiency have negative influence on the quality of life of the AR patients.更多还原