【摘要】 目的通过Meta分析评估大气污染对儿童变应性鼻炎患病风险的影响。方法检索Pub Med、Science、Google Scholar、MDPI等数据库,检索时间均为2012-01-01²017-07-01,纳入大气污染与儿童变应性鼻炎相关的观察类研究。用Combie横断面研究评价工具和NewcastleOttawa Scale（NOS）文献质量评价量表进行文献质量评定。以具有代表性的大气污染物（NO₂、SO₂、PM₁0）与儿童变应性鼻炎发病风险关联的OR及其95%置信区间作为效应量,采用Review Manager 5.3软件行异质性分析和发表偏倚检验,合并分析效应值。结果最终将纳入的6篇文献行Meta分析。（1）6篇研究报道了NO₂暴露与儿童变应性鼻炎患病风险的关联,随机效应模型结果显示,NO₂会导致儿童变应性鼻炎患病风险增高,结果OR_合并=1.22,95%CI[1.04,1.42],P=0.01。（2）5篇文献对SO₂暴露与儿童变应性鼻炎患病风险进行了报道,结果OR_合并=1.06,95%CI[0.96,1.18],P=0.2 3,无统计学意义。（3）6篇P M₁0相关文献O R_合并=1.13,95%CI[1.04,1.23],P=0.004,PM₁0的暴露会增加儿童变应性鼻炎的患病风险。结论大气污染是儿童变应性鼻炎患病的危险因素,NO₂与PM₁0的暴露会增加儿童变应性鼻炎患病风险。更多还原

【Abstract】 OBJECTIVE To carry out a meta analysis on the results of all conducted studies to present valid information about the impact of air pollution exposure on the risk of allergic rhinitis in children. METHODS PubMed,Science, Google Scholar and MDPI database were searched up to January 1, 2012 to July 1, 2017, including the observational studies about air pollution and children with allergic rhinitis.Combie cross-sectional study evaluation tool and NOS scale were used to evaluate the quality of literature. The odds ratio of representative air pollutants（NO₂, SO₂, PM₁0） exposed to the risk of allergic rhinitis in children and it 95% confidence interval as effects, and based on the heterogeneity analysis and publication bias test of Review Manager 5.3 software.The effects were analyzed by fixed or random effects model.RESULTS Finally, 6 studies were included in the meta analysis（4 cross-sectional studies, 2 cohort studies）. The results showed that exposure to nitrogen dioxide increased the risk of allergic rhinitis（OR=1.22, 95%CI [1.04, 1.42],P =0.01）, exposing tosulfur dioxideincreased the risk of allergic rhinitis（OR =1.06, 95%CI [0.96, 1.18], P =0.23）,and PM₁0 increased the risk of allergic rhinitis（OR=1.13,95%CI [1.04, 1.23], P =0.004）. CONCLUSION Air pollution is a risk factor for allergic rhinitis in children, and the risk of allergic rhinitis will be increase when exposed to NO₂ and PM₁0.更多还原