Objective To explore the intrinsic connection between activation of classical nuclear factor-κB(NF-κB) pathway and gefitinib resistance in human lung adenocarcinoma H1650 cells. Methods Human lung adenocarcinoma H1650 cells were exposed to gefitinib continuously for 60 days to obtain resistant H1650 cells. The expressions of P-IκBα, P-p50 and P-p65 in the cytoplasm or nuclei were detected using Western blotting in human lung adenocarcinoma HCC827 cells, parental H1650 cells and gefitinib-resistant H1650 cel...
【基金】
珠海市科技计划医疗卫生项目(一般项目)(20161027E030026)
【更新日期】
2018-06-19
【分类号】
R734.2
【正文快照】
东珠海519000Activation of nuclear factor-κB subunit p50/p65 enhances gefitinib resistance of lungadenocarcinoma H1650 cell linePAN Ying1,HUANG Sichao2,WANG Xia3,GONG Wuxing1,LIANG Cuiwei1,DU Junxiang1,PENG Dongxu1,XIE Yun1,ZHENGLiping1,ZHANG Nan1,QUAN We
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