【摘要】 目的研究金樱子胶囊对四氯化碳(CCl4)诱导小鼠急性肝损伤的保护作用。方法昆明小鼠随机分为空白对照组、模型组和金樱子胶囊不同剂量(100 mg/kg、200 mg/kg、400 mg/kg,ig)给药组;给药7 d后,以腹腔注射0.4%CCl4花生油溶液(0.1 m L/10 g)的方法建立急性肝损伤模型,HE染色观察小鼠肝脏组织病理学损伤,试剂盒检测小鼠血清谷草转氨酶(AST)、谷丙转氨酶(ALT)及肝组织超氧化物歧化酶(T-SOD)、丙二醛(MDA)、谷胱甘肽(GSH)、谷胱甘肽过氧化物酶(GSH-PX)含量。结果金樱子胶囊能显著改善肝脏组织损伤,逆转CCl4诱导的小鼠肝中SOD、GSH-PX、GSH活力下降,降低MDA含量,并显著降低血清中AST和ALT的含量。结论金樱子胶囊可显著改善小鼠肝中氧化应激水平,对CCl4诱导的小鼠急性肝损伤具有一定的保护作用。更多还原

【Abstract】 Objective To observe the protective effect of Rosa laevigata Michx capsule against liver injury in mice induced by carbon tetrachloride（ CCl₄）. Methods Mice were randomly divided into the control group,the model group and different doses of Rosa laevigata Michx health food group [100 mg/（ kg·d）,200 mg/（ kg·d）,400 mg/（ kg·d） ]. After administration 7 d,we established the model of liver injury via intraperitoneal injection of 0. 4%（ CCl₄）（ 0. 1 mL/10 g）,andthen observe the pathology changes. Furthermore,we detected AST and ALT levels in serum,and MDA,SOD,GSH and GSH-PX levels in hepatic tissue. Results Rosa laevigata Michx capsule could notably improved the injury of liver tissue and significantly increased liver SOD,GSH-PX and GSH activities and remarkably decreased MDA,AST and ALT in mice after treated by CCl₄. Conclusions Rosa laevigata Michx capsule has a protective effect against liver injury in mice induced by CCl₄ through regulating oxidative stress levels.更多还原