【摘要】 目的:揭示儿童EB病毒(Epstein-Barr virus,EBV)感染后肝功能变化和细胞免疫状态的关系,为儿童EBV感染临床诊疗提供依据。方法:回顾性收集2017年4月1日至9月30日首都儿科研究所附属儿童医院住院确诊为EBV感染病例的临床和实验室检测资料,对EBV感染肝功能异常组和肝功能正常组患儿的性别、年龄、确诊疾病种类以及T细胞、辅助/诱导T细胞、调节/抑制T细胞、CD4+/CD8+比值、B细胞、自然杀伤(natural killer,NK)细胞、总淋巴细胞指标进行统计学分析。结果:共75例EBV感染住院儿童,发生肝功能异常者34例,未发生肝功能异常组41例;肝功能异常组和肝功能正常组患儿性别比例(χ2=0. 077,P=0. 783)、年龄均值(t=1. 042,P=0. 301)差异均无统计学意义; T细胞(t=1. 943,P=0. 058)、B细胞(t=1. 741,P=0. 088)、NK细胞(t=0. 523,P=0. 603)、总淋巴细胞(t=0. 915,P=0. 365)指标差异均无统计学意义;辅助/诱导T细胞(t=5. 161,P=0. 000)、调节/抑制T细胞(t=5. 446,P=0. 000)、CD4+/CD8+比值(t=4. 031,P=0. 000)指标差异均有统计学意义。结论:调节性细胞免疫功能紊乱可能是儿童EBV感染肝功能异常的原因之一。更多还原

【Abstract】 Objective: To disclose the relationship between the changes of liver function and cellular immunological state of children with Epstein-Barr virus( EBV) infection,which provides the basis for clinical diagnosis and treatment of EBV infection of children.Methods: The clinical and laboratory test data of hospitalized children diagnosed with EBV infection from April 1 to September 30,2017 in Children’s Hospital Affiliated to the Capital Institute of Pediatrics were retrospectively collected. The indexes of gender,age,disease type,T cells,helper/induction T cells,regulation/suppression T cells,CD4+/CD8+ratio,B cells,natural killer( NK) cells and total lymphocytes in normal and abnormal liver function group were statistically analyzed. Results: 34 cases occurred liver dysfunction in 75 cases of hospitalized children with EBV infection,and 41 cases didn’t occurre liver dysfunction. The differences of the gender proportion( χ2= 0. 077,P = 0. 783),mean age( t = 1. 042,P = 0. 301),T cells( t = 1. 943,P = 0. 058),B cells( t = 1. 741,P = 0. 088),NK cells( t = 0. 523,P = 0. 603),total lymphocytes( t = 0. 915,P = 0. 365) between the normal group and abnormal liver function group were all not statistically significant. However,the differences of helper/induction T cells( t = 5. 161,P = 0. 000),regulation/inhibition T cells( t = 5. 446,P = 0. 000),CD4+/CD8+ratio( t = 4. 031,P = 0. 000) between the normal group and abnormal liver function group were all statistically significant. Conclusion: The regulatory cellular immune dysfunction perhaps is one of the reasons caused the abnormal liver function of children with EBV infection.更多还原