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疏肝健脾法治疗乙肝后肝硬化临床应用概述

Research Progress of Liver-Soothing and Spleen-Invigorating Therapy in the Treatment of Post-Hepatitis B Cirrhosis

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【作者】 张涛张斌吴眉朱晓骏史运峰刘梅

【Author】 ZHANG Tao;ZHANG Bin;WU Mei;ZHU Xiaojun;SHI Yunfeng;LIU Mei;Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine;Shanghai Seventh People’s Hospital;

【通讯作者】 张斌;

【机构】 上海中医药大学附属曙光医院上海市第七人民医院

【摘要】 西医抗病毒药物虽然能够抑制乙肝后肝硬化的病毒复制,但尚无针对肝硬化的药物应用于临床。中医药能够多环节和多途径地改善肝硬化。本病的基本病机为本虚标实,湿热疫毒为致病之标,脾土衰败为病机之本。湿热疫毒侵袭肝脏,肝旺乘脾,脾气受损,气血生化乏源,病程日久则正气亏虚,虚损生积。肝主疏泄,调气机,畅血行;脾主运化,喜燥而恶湿,脾气升则健。肝脾同属中焦,木赖土以培之,土得木而达之,故宜肝脾同治。疏肝以理气,养血,活血为主;健脾以益气,温中,化湿为要。疏肝健脾体现了中医"整体观念"和"未病先防,既病防变"的理论精华,贯穿于乙肝后肝硬化治疗的始终。

【Abstract】 Although western antiviral drugs can inhibit the viral replication of post-hepatitis B cirrhosis, there is no drug for liver cirrhosis applied in clinical practice. Traditional Chinese medicine can improve liver cirrhosis in many links and ways.The basic pathogenesis of the disease is deficiency in origin and excess in superficiality. Dampheat and pestilent toxinare the main causes of the disease, and decay of spleen is the origin of pathogenesis. Damp-heat and pestilent toxin attack liver, then spleen is invaded by liver qi. The deficient spleen cannot produce qi and blood, and then lead to the formation of cirrhosis. The main function of the liver is to regulate the qi and blood flow. The spleen governs movement and transformation and it prefers dryness to dampness. The spleen rises strongly. The liver and spleen are belong to middle jiao. The wood depends on the soil and the soil is free with the help of wood. So the liver and spleen are treated simultaneously. The treatment of liver is mainly in the method of regulating qi, nourishing blood and activating blood. Thetreatment of spleen is benefiting qi, warming spleen and stomach and resolving dampness. Soothing liver and invigorating spleen therapy embodies the theoretical essence of "whole concept" and "prevention before disease, prevention of change of disease" of traditional Chinese medicine, which runs through the treatment of post-hepatitis B cirrhosis.

【基金】 国家自然科学基金面上项目(81774256);国家自然科学青年科学基金项目(81403351);上海中医药大学预算内项目(2014YSN46);上海中医药大学附属曙光医院四明青年基金(SGKJ-201718)
  • 【文献出处】 长春中医药大学学报 ,Journal of Changchun University of Chinese Medicine , 编辑部邮箱 ,2018年06期
  • 【分类号】R259
  • 【被引频次】15
  • 【下载频次】215
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