【摘要】 目的研究影响复发胶质母细胞瘤(GBM)患者预后的因素,对复发患者再次治疗效果进行探讨。方法采用回顾性分析方法,收集2008年3月至2013年3月,该院神经外科收治的36例复发性GBM再治疗患者的临床及随访资料,进行预后影响因素的分析。结果单个因素分析结果表明,性别、切除程度、治疗方式、首次方案对无进展生存期影响,差异有统计学意义(P<0.05);切除程度对总生存期的影响,差异有统计学意义(P<0.05)。多因素分析结果表明,KPS评分、切除程度、治疗方式对无进展生存期影响,差异有统计学意义(P<0.05),切除程度对总生存期影响,差异有统计学意义(P<0.05)。结论复发GBM仍有手术机会全切者,再次治疗能达到缓解症状、提高生活质量、延长生存期的效果。更多还原

【Abstract】 Objective To study the factors influencing prognosis in the patients with recurrent glioblastoma muhiforme(GBM)and to investigate the effect of retreatemt.Methods The retrospective analysis method was adopted to collect the clinical and follow up data in 36 cases of recurrent GBM retreatment in the neurosurgery department of this hospital from March 2008 to March 2013.The prognosis influencing factors were analyzed.Results The univariate analysis results showed that the gender,resection degree,treatment mode and initial scheme had the influence on the progression free survival(P<0.05).The resection degree had an impact on the overall survival(P<0.05).The multivariate analysis results showed that KPS score,resection degree and treatment mode had effect on the progression free survival(P<0.05).The resection degree had an influence on the overall survival(P<0.05).Conclusion If the patients with recurrent GBM still has the chance of operation whole excision,the re-treatment can reach the effect for relieving the symptoms,improving the quality of life and prolonging the survival period.更多还原