【摘要】 目的观察自噬相关蛋白LC3、Raptor、Rictor在甲状腺乳头状癌中表达情况,分析其与临床病理因素之间的关系。方法采用免疫组织化学法检测LC3、Raptor、Rictor在甲状腺乳头状癌及其癌旁组织中的表达情况,并结合临床病理因素进行分析。结果 LC3、Raptor、Rictor在甲状腺乳头状癌中的阳性表达率分别为76. 7、82. 5、41. 7%,在癌旁组织中的阳性表达率分别为4. 9、16. 5、7. 8%,三项指标的表达差异均有统计学意义。LC3的表达与肿瘤长径及砂砾体形成相关,Raptor、Rictor的表达均与TNM分期相关,Rictor的表达与淋巴结转移相关。结论 LC3、Raptor、Rictor在甲状腺乳头状癌中表达升高,对于甲状腺乳头状癌的诊断、判断预后方面具有潜在价值。更多还原

【Abstract】 Objective To investigate the expression of LC3,Raptor and Rictor in papillary thyroid carcinoma and elucidate the relationship between LC3,Raptor,Rictor and cancer clinical pathological factors. Methods Immunohistochemical method was used to detect LC3,Raptor and Rictor expression. The relationship with expression of LC3,Raptor,Rictor and clinicopathological factors was analyzed. Results The positive rates of LC3,Raptor and Rictor in papillary thyroid carcinoma were 76. 7,82. 5 and 41. 7% respectively,but they were 4. 9,16. 5 and 7. 8%,respectively in the adjacent tissues. The difference was statistically significant. LC3 was correlated with tumor size and psammoma bodies,High expressions of Raptor and Rictor were significantly correlated with TNM grade,and Rictor was correlated with lymph node metastasis. Conclusion The expression of LC3,Raptor and Rictor were up-regulated in papillary thyroid carcinoma,and they were considered to have potential value for the diagnosis and prognosis of papillary thyroid carcinoma.更多还原