【摘要】 目的:观察从风湿证辨证治疗IgA肾病的临床疗效。方法:入组浙江省15家医院符合入选标准的原发性IgA肾病患者193例,治疗组97例予中药祛风湿组方+西医基础治疗,对照组96例予中药祛风湿组方模拟剂+西医基础治疗,疗程12周,评价两组患者实验室指标、中医证候积分和安全性。结果:按方案完成试验174例,其中治疗组96例,对照组78例。(1)治疗后治疗组24h尿蛋白定量和血肌酐降低、肾小球滤过率(eGFR)上升,总体临床疗效治疗组优于对照组(P<0.05,P<0.01)。(2)中医证候疗效分析,两组总有效率无明显差异,但以缓解率+显效率分析,治疗组显著优于对照组(P<0.05)。(3)两组间安全性分析无显著差异。结论:祛风湿组方治疗以风湿证为主的原发性IgA肾病可以改善其临床症状及实验室指标。更多还原

【Abstract】 Objective: To observe the clinical efficacy of treating Ig A nephropathy from wind-damp syndrome. Methods: Enter of 193 Ig A nephropathy patients that meet the criteria from 15 hospitals in Zhejiang province, of which 97 cases in treatment group(dispelling wind and eliminating dampness TCM prescription with western medicine foundation treatment) and the other 96 cases in control group(TCM simulator with western medicine foundation treatment). After 12 weeks treatment course, above two groups are evaluated by laboratory evaluation index, the TCM syndrome integral, and security. Results: A total of 174 cases completed the program, 96 cases in treatment group and 78 cases in the control group.(1)After treatment, both groups have 24-hour urinary protein quantity and serum creatinine reduced, e GFR increased, but the treatment group was better than the control group(P<0.05, P<0.01). Analyzing the therapeutic effect of TCM, the total efficiency of two groups have no significant difference, but the treatment group is superior to the control group in rate of remission and significant efficiency.(2)There was no statistical difference between two groups in security. The treatment group’s remission rate+effective rate were significantly better than the control group’s(P<0.05).(3)There was no significant difference of safety analysis between the two groups. Conclusion: The treatment with dispelling wind and eliminating dampness TCM prescription can improve the clinical symptoms and laboratory indexes in Ig A nephropathy patients with wind-damp syndrome.更多还原