【摘要】 目的:研究心率变异性以及血浆NT-pro BNP水平对冠状动脉病变程度的临床评估效果。方法:检查200例冠心病患者的心率变异性以及血浆N端脑钠肽前体（NT-pro BNP）水平,按照冠脉造影后的Syntax评分分为高危组（33例）、中危组（57例）、低危组（72例）、对照组（38例）,比较四组的SDANN、SDNN、PNN50、r MSSD以及血浆NT-pro BNP水平。结果:对照组SDANN、SDNN、PNN50、r MSSD高于其他组（P<0.05）,对照组血浆NT-pro BNP水平低于其他组（P<0.05）,心率变异性与冠状动脉病变程度呈负相关(r_PNN50=-0.41,r_SDNN=-0.39,r_SDANN=-0.38,r_{r MSSD}=-0.29;P<0.05),血浆NT-pro BNP水平与冠状动脉病变程度呈正相关（r=0.92,P<0.05）。结论:心率变异性以及血浆NT-pro BNP水平可作为临床上评估冠状动脉病变程度的指标。更多还原

【Abstract】 Objective: To explore the clinical evaluation effect of heart rate variability and plasma NT-pro BNP level on the degree of coronary artery disease. Methods: The heart rate variability and plasma NT-pro BNP levels for 200 cases of coronary heart disease were detected and according to the Syntax score after coronary angiography,all patients were divided into high-risk group（ 33 cases）,moderate group（ 57 cases）,low-risk group（ 72 cases） and normal group（ 38 cases）. The levels of SDANN,SDNN,PNN50,r MSSD and plasma NT-pro BNP were compared in the four groups. Results: SDANN,SDNN,PNN50 and r MSSD in the control group were higher than other groups（ P < 0. 05）. The plasma NT-pro BNP level in the control group was lower than that in the other groups（ P < 0. 05）. Heart rate variability was negatively correlated with the degree of coronary artery disease( r_PNN50=-0. 41; r_SDNN=-0. 39; r_SDANN=-0. 38; r_RMSSD=-0. 29); the level of plasma NT-pro BNP was positively correlated with the degree of coronary artery disease（ r = 0. 92）. Conclusion: The heart rate variability and plasma NT-pro BNP level can be used as clinical indicators to evaluate the degree of coronary artery disease.更多还原