【摘要】 目的:探讨弥散加权成像-表观扩散系数（DWI-ADC）值对乳腺癌及腋窝淋巴结性质的诊断价值。方法:对37例可疑乳腺癌组织和15例对侧正常腺体行MRI检查并计算ADC值。37例乳腺肿块性质根据术后病理结果确诊。结果:（1）乳腺正常腺体、良性包块及恶性占位的平均ADC值分别为（1.841±0.801）×10^-3 mm²/s、（1.410±0.099）×10^-3 mm²/s和（0.942±0.148）×10^-3 mm²/s,三组间差异有统计学意义（F=257.7,P<0.05）。（2）取乳腺恶性病变ADC值的95%可信区间的上界1.010×10^-3 mm²/s作为诊断乳腺癌的阈值,诊断的敏感性、特异性和准确性分别为85.71%、87.50%和86.49%。（3）转移性淋巴结和良性增生淋巴结的ADC值分别为（0.872±0.102）×10^-3 mm²/s和（1.061±0.122）×10^-3 mm²/s,两者差异有统计学意义（t=6.462,P<0.05）。（4）取转移性淋巴结ADC值的95%可信区间的上界0.937×10^-3 mm²/s作为诊断转移性淋巴结的阈值,诊断的敏感性、特异性和准确性分别为52.94%、88.89%和65.38%。结论:DWI-ADC值对乳腺癌的诊断以及腋窝淋巴结性质的判断均具有较高的敏感性、特异性及准确性。更多还原

【Abstract】 Objective:To investigate the values of ADC in evaluation of breast cancer and axillary lymph metastases.Methods:A total of 37 cases with suspected breast cancer and 15 cases with normal side breast were examined by MRI and calculated the ADC value.The nature of breast mass was confirmed by pathological test.Results:The average ADC values were（1.841±0.801）×10^-3 mm²/s,（1.410±0.099）×10^-3 mm²/s and（0.942±0.148）×10^-3 mm²/s in the normal group,benign and malignant group,respectively.There were significant differences among three groups（F=257.7,P<0.05）.The upper limit of95%confidence interval in breast cancer group was 1.010×10^-3 mm²/s,and the diagnostic sensitivity,specificity and accuracy were 85.71%,87.50% and 86.49%,respectively.The average ADC values were（0.872±0.102）×10^-3 mm²/s and（1.061±0.122）×10^-3 mm²/s in the metastatic and benign lymph node,respectively,with a significant difference between two groups（t=6.462,P<0.05）.The upper limit of 95% confidence interval in metastatic lymph was 0.937×10^-3 mm²/s,and the diagnostic sensitivity,specificity and accuracy were 52.94%,88.89% and 65.38%,respectively.Conclusion:DWI-ADC value has high sensitivity,specificity and accuracy in diagnosis of breast cancer and assessment of axillary lymph node property.更多还原