【摘要】 目的研究游离自体心包补片修复气管膜部缺损的可行性。方法选8条成年实验犬为研究对象。右后外侧切口进胸取实验犬心包壁作为补片移植物。暴露实验犬颈部气管,切除环状软骨下方第四气管环水平部分膜部形成约2 cm×2 cm大小全层缺损,并使用心包补片移植物修补受损气管膜部缺损。术后使用纤维支气管镜检查气管通畅度。实验犬存活至术后6个月实施安乐死,取气管标本计算收缩率,并进行组织学检查。结果所有实验犬均未出现手术并发症,支气管镜检查未发现吸气或者呼气时气管塌陷。气管断面最狭窄部位与补片下第三软骨环部位之比平均为1.07±0.03。组织学检查显示所有补片移植物表面新生纤毛柱状上皮。结论心包补片移植物修补气管膜部缺损安全且有效。更多还原

【Abstract】 Objective To investigate the feasibility of repairing the defective tracheal membranous walls with autogenous pericardium patch grafts. Methods The pericardium of 8 adults dogs were harvested though chest posterolateral incision and used as patch grafts. The cervical trachea were exposed and the full-thickness lesion(2 cm × 2 cm) were formed in the horizontal part of the fourth tracheal ring below the cricoid cartilage. And then the defect was repaired by grafting a pericardium patch to the posterior surface of the injured. Bronchoscopy was used to examine the patency of the trachea after operation. After 6 months, euthanasia was performed in the experimental dogs. Tracheal specimens of dogs were taken to calculate the contractile rate and histological examination was performed. Results There was no operative complications occurred in all experimental dogs until 6 months after the operation. Bronchoscopic examination demonstrated adequate tracheal patency with no inspiratory or expiratory collapse. The constrictive ratio of the cross-sectional area of the most stenotic site to that of the third tracheal ring below the membranous patch was 1.07±0.03. Histologic examination revealed that neoepithelium were reborn on the surfaces of all the patch grafts. Conclusion It is safe and effective to repair tracheal membranous wall in pericardium patch grafts.更多还原