The occurrence of 22 antibiotics in water samples, sediments, fish and shellfish in aquaculture area of the Pearl River Estuary(Zhuhai and Daya Bay) was studied, using ultrasonic extraction combined with ultraperformance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS). The main pollutants detected in aquaculture area of the Pearl River Estuary are quinolones such as norfloxacin, ofloxacin, ciprofloxacin and flumequine. Higher ∑antibiotics were observed in Zhuhai Bay in water and sediments compare...