【摘要】 目的探讨磁共振扩散张量成像(DTI)对乳腺癌的诊断价值。方法回顾性分析116例乳腺病变(包括乳腺癌54例,乳腺良性病变62例)患者的影像学资料,所有患者均行磁共振成像(MRI)常规扫描、增强扫描和DTI检查,比较病变部位与健侧腺体组织的DTI参数,并分析不同DTI参数对乳腺癌诊断的敏感度和特异度。结果乳腺癌组织的平均扩散程度(MD)、各向异性指数(FA)、λ1值及乳腺良性病变组织的MD、λ1值均明显低于自身健侧腺体组织,差异均有统计学意义(P﹤0.01);乳腺癌组织的MD、λ1值分别为(1.00±0.30)×10-3、(1.12±0.24)×10-3mm2/s,均明显低于乳腺良性病变组织的(1.51±0.22)×10-3、(1.80±0.21)×10-3mm2/s,差异均有统计学意义(P﹤0.01);MD、FA、λ1值对乳腺良、恶性病变诊断的ROC曲线下面积(AUC)分别为0.945、0.640、0.988;MD、FA、λ1值诊断乳腺良、恶性病变的敏感度和特异度分别为83.50%和91.20%,45.00%和80.00%,100%和95.80%。结论DTI对乳腺良、恶性病变的诊断鉴别有重要的意义,MD、λ1值对乳腺癌诊断敏感度、特异度较高。更多还原

【Abstract】 Objective To evaluate the value of magnetic resonance diffusion tensor imaging(DTI) in the diagnosis of breast cancer. Method The imaging data of 116 patients with breast lesions(including 54 cases of breast cancer and 62 cases of benign breast lesions) diagnosed by routine magnetic resonance imaging(MRI) scan, enhanced scan and DTI examination were retrospectively analyzed. DTI parameters were measured and compared between lesions and normal gland tissues of uninjured side, and the sensitivity and specificity of different DTI parameters for the diagnosis of breast cancer were analyzed. Result Compared with the uninjured contralateral gland tissue, the mean diffusion(MD), fractional anisotropy(FA) and λ1 value of breast cancer were significantly lower(P<0.01), and the MD and λ1 value of benign breast lesions were also significantly lower(P<0.01). The MD and λ1 value of breast cancer [(1.00 ± 0.30) × 10-3,(1.12 ±0.24)×10-3 mm2/s] were significantly lower than those of benign breast lesions [(1.51±0.22)×10-3,(1.80±0.21)×10-3 mm2/s](P<0.01). The area under curve(AUC) of ROC for MD, FA and λ1 value for the diagnosis of benign and malignant breast lesions was 0.945, 0.640 and 0.988, respectively. The sensitivity and specificity of MD, FA and λ1 value in the diagnosis of benign and malignant breast lesions were 83.50% and 91.20%, 45.00% and 80.00%, 100% and 95.80%, respectively.Conclusion DTI is of important significance in the diagnosis of benign and malignant breast lesions and the differentiation of benign from malignant breast lesions. MD and λ1 are predictive values with high sensitivity and specificity for the diagnosis of breast cancer.更多还原