【摘要】 目的探讨肥胖、非酒精性脂肪肝(NAFLD)与胆囊结石、胆囊息肉发病率相关性。方法选择2012—2016年在西安交通大学第一附属医院体检中心连续查体,2016年新发胆囊结石或胆囊息肉患者306例,其中胆囊息肉239例,胆囊结石67例,年龄范围为30～80岁,匹配职业、年龄、性别、空腹血糖、血压,健康对照组765例,测患者身高、体质量,计算体质量指数(BMI),测空腹血糖、血压,肝胆胰脾超声,STSS 19. 0统计软件处理,X~2检验分析两组胆囊结石或胆囊息肉发病率; logistic相关回归分析胆囊结石或胆囊息肉发病相关因素。结果 BMI≥24 kg·m-2组胆囊结石或胆囊息肉发病率明显高于BMI <24kg·m-2组,两组之间差异有统计学意义(X~2=11. 119,P=0. 001),NAFLD组与无NAFLD组胆囊结石或胆囊息肉发病率比较,差异无统计学意义(X~2=2. 832,P=0. 092),超重合并NAFLD组胆囊结石或胆囊息肉发病率明显高于未超重且无NAFLD组(X~2=5. 930,P=0. 015)。多因素logistic分析提示,超重与胆囊结石或胆囊息肉发病关联(OR=24. 457,95%CI:11. 080～53. 983,P <0. 001),NAFLD与胆囊结石或胆囊息肉发病关联性不大(OR=0. 633,95%CI:0. 394～1. 017,P=0. 058)。结论肥胖是胆囊结石或胆囊息肉发病的独立危险因素,NAFLD可能协同肥胖促进该类疾病发生。更多还原

【Abstract】 Objective To investigate the correlation between obesity,nonalcoholic fatty liver disease and morbidity of gallstone or gallbladder polyps. Methods At The First Affiliated Hospital of Xi’an Jiaotong University healthy examination center,we found 306 newonset patients with gallstone or gallbladder polyps in 2016,including 239 gallbladder polyps and 67 gallstone patients,whose age were between 30 and 80 years old. And in the controls,there were 765 persons matched for age,gender,fasting blood glucose,blood pressure,living environment. We calculated their body mass index(BMI) by measuring height and weight,tested their fasting blood glucose,blood pressure,and measured their hepatobiliary ultrasound. We analysed the difference of incidence of gallstones or gallbladder polyps between the two groups by chi square test,and the association between the overweight,NAFLD and incidence of gallstones or gallbladder polyps by logistic regression analysis using SPSS 19. 0 statistical software. Results The incidence of cholecystolithiasis or gallbladder polyps in the overweight group was significantly higher than that of the BMI < 24 kg·m-2 group(X~2= 11. 119,P = 0. 001). The incidence of cholecystolithiasis or gallbladder polyps in the NAFLD group was not significantly higher than that of the Non-NAFLD(X~2=2. 832,P = 0. 092),while the incidence of cholecystolithiasis or gallbladder polyps in the NAFLD group with overweight was not significantly higher than that of the Non-NAFLD without overweight(X~2= 5. 930,P = 0. 015). Multivariate analysis logistic showed that overweight was associated with cholecystolithiasis or gallbladder polyps(OR = 24. 457,95 % CI: 11. 080-53. 983,P < 0. 001),and there was no significant correlation between NAFLD and gallstones or gallbladder polyps(OR = 0. 633,95 % CI: 0. 394-1. 017,P = 0. 058).Conclusion The obesity is an independent risk factor for gallstone or gallbladder polyps,and NAFLD may promote the occurrence of such diseases as a result of being complicated by overweight.更多还原