【摘要】 野生型p53基因是抑癌基因,作为基因表达的一个主调控因子,p53能直接或间接调控许多蛋白编码基因和非编码RNA的表达,包括微小RNA(microRNA,miRNA)和长链非编码RNA(long non-coding RNA,lncRNA)。lncRNA在调控不同细胞过程,如干细胞多能性、发育、细胞生长和凋亡以及癌症转移中发挥重要作用。许多研究表明一些lncRNA可作为癌基因或抑癌基因参与了p53肿瘤抑制调控网络途径。现对p53相关lncRNA在肿瘤发生发展中作用的研究作一论述。更多还原

【Abstract】 Wild-type p53 gene is a tumor suppressor gene. As a major regulator of gene expression,p53 can directly or indirectly regulate many protein-coding genes and noncoding RNAs,including microRNA( miRNA) and long-chain noncoding RNA( long noncoding RNA,lncRNA). LncRNA plays an important role in the regulation of different cellular processes,such as stem cell pluripotency,development,cell growth and apoptosis,and cancer metastasis. Many studies have shown that some lncRNAs can act as oncogenes or tumor suppressor genes involved in the p53 tumor suppressor regulatory network pathway. Therefore,this short review will focus on the role of p53-related lncRNA in tumorigenesis and progression.更多还原