【摘要】 目的系统评价牙周病与胃癌发生风险的相关性。方法计算机检索PubMed、EMbase、CNKI、WanFang Data、VIP和CBM数据库中关于牙周病与胃癌相关性的研究,检索时限均为建库至2017年1月31日。由2位研究员独立筛选文献、提取资料并评价纳入研究的偏倚风险后,采用RevMan 5.3软件进行Meta分析。结果共纳入5个研究。Meta分析的结果显示:牙周病与胃癌之间无相关性[RR=0.99,95%CI(0.83,1.19),P=0.93],敏感性分析结果表明稳定性良好。亚组分析结果显示不同研究类型、种族和效应值类型对结果没有影响,牙周病与胃癌之间仍无相关性。结论当前证据表明牙周病不是胃癌发病的危险因素。受纳入研究数量和质量的限制,上述结论尚待更多高质量研究予以验证。更多还原

【Abstract】 Objective To systematically review the relationship between periodontal disease and gastric cancer risk. Methods We retrieved PubMed, EMbase, CNKI, WanFang Data, VIP, and CBM databases to collect studies about the correlation between periodontal disease and gastric cancer from inception to January 31 st, 2017. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies. Then, meta-analysis was performed using RevMan 5.3 software. Results Five studies were included. The results of meta-analysis showed that there was no significant correlation between periodontal disease and gastric cancer(RR=0.99, 95%CI 0.83 to 1.19, P=0.93).Sensitivity analysis showed good stability. Subgroup analysis showed that the type of study, race and type of effect size have no statistically impact on the outcome, there was no significant correlation between periodontal disease and gastric cancer. Conclusion According to the current evidence, periodontal disease probably is not a risk factor of gastric cancer.Due to limited quality and quantity of the included studies, more high quality studies are needed to verify above conclusion.更多还原