【摘要】 目的寻找新结构的抗肿瘤先导化合物。方法将芳香醛与2,4-二硝基苯肼缩合制备得到4个新的硝基苯席夫碱衍生物（1-4）。并利用¹HNMR、¹³C NMR、HR-MS、FT-IR等对其进行结构表征,化合物1经单晶XRD测试。采用MTT法对A549（人肺腺癌细胞）和HepG2（人源肝癌细胞）耐药细胞株进行体外抗肿瘤活性初步筛选。结果化合物4对A549（人肺腺癌细胞）和HepG2（人源肝癌细胞）具有中等活性。结论得到的系列硝基苯席夫碱化合物为今后的深入抗肿瘤活性研究与实践奠定了实验基础。更多还原

【Abstract】 Objective To discover novel lead compounds for antitumor researches. Methods Four Schiff base derivatives（1-4） were obtained by conventional synthesis of aromatic aldehyde and 2,4-Dinitrophenylhydrazine,and their structures were characterized by ¹ H NMR,¹³C NMR,HR-MS and FT-IR spectrum. Compound 1 was further tested by single-crystal XRD techniques. Their anticancer activities were investigated against A-549 and HeGp2 cell lines by MTT assay. Results Compound 4 exhibited middle anticancer activities on the two human cancer cells. Conclusion Four Schiff base derivatives are synthesized,which serves as a good basis for further research of anticancer activities and practice.更多还原