【摘要】 目的讨论D、G组染色体随体多态性对生殖异常的影响及其产生的临床效应。方法在我中心行遗传咨询及辅助生殖的生殖异常夫妇4001对,进行外周血染色体制备及核型分析。结果检出D、G组染色体随体变异71例,其在人群中的发生率为0.89%(71/8002),其中13p+6例,占0.07%(6/8002),14p+11例,占0.14%(11/8002),15p+21例,占0.26%(21/8002),21p+21例,占0.26%(21/8002),22p+12例,占0.15%(12/8002)。结论 D、G组染色体多态性与不孕不育、反复自然流产、少弱精子症、生育智低儿、畸形儿等临床生殖异常有相关性。更多还原

【Abstract】 Objective:To discuss the influence of D-banding/G-banding chromosomal polymorphism to reproduction abnormality and generated clinical effect. Methods:To set up peripheral blood culture among 4001 cases of couples who have undertaken genetic counseling and assisted reproduction in our center. Results:71 cases of D-banding/G-banding abnormalities were detected among 8002 patients with the ratio of 0.89%(71/8002). Among them,6 cases were 13p+ with the ration of 0.07%(6/8002),11 cases were 14p+ with the ratio of 0.14%(11/8002),21 cases were 15p+ with the ratio of 0.26%(21/8002),21 cases were 21p+ with the ratio of 0.26%(21/8002)and 12 cases were 22p+ with the ratio of 0.15%(12/8002). Conclusion:D-banding/G-banding chromosomal polymorphism had relativity to clinical reproduction abnormalities such as infertility,recurrent spontaneous abortion,Oligoasthenospermia and reproduction of baby with low intelligence or birth defect,etc.更多还原