【摘要】 目的采用定量磁敏感成像(QSM)技术探讨正常青年人不同侧别及性别的脑磁化率。方法对41名健康右利手青年人行常规头颅MRI和QSM扫描,通过后处理软件对图像处理获得磁敏感图,然后手工勾画双侧额叶灰质(FGM)、额叶白质(FWM)、尾状核(CA)、苍白球(GP)、壳核(PU)、丘脑(TH)、黑质(SN)、红核(RN)、齿状核(DN)、桥脑(PO)、胼胝体(CC)的ROI并获得磁化率。对各ROI的磁化率采用Mann-Whitney秩和检验比较不同侧别和性别磁化率的差异。结果双侧ROI磁化率GP最高,SN次之,FWM最低;双侧FGM、FWM、CA、GP、PU、TH、SN、RN、DN、PO、CC的ROI磁化率差异均无统计学意义(P均>0.05)。不同性别CA的磁化率差异有统计学意义(P<0.05)。结论通过QSM测定脑磁化率,可评估脑铁含量。更多还原

【Abstract】 Objective To explore the changes of susceptibility of different sides and gender in healthy young adults with quantitative susceptibility mapping(QSM).Methods Totally 41 healthy young right-handed adults underwent conventional brain MRI and QSM scan,and the susceptibility maps were obtained by the image post-processing software.Then the ROI of the bilateral frontal grey matter(FGM),frontal white matter(FWM),caudate(CA),globus pallidus(GP),putamen(PU),thalamus(TH),substantia nigra(SN),red nucleus(RN),dentate nucleus(DN),pons(PO),corpus callosum(CC)were manually drawn to obtain magnetic susceptibility on the susceptibility map.The magnetic susceptibility of each ROI was compare between both sides,as well as gender by Mann-Whitneytest.Results The magnetic susceptibility of the bilateral ROI of GP was the highest,and SN was followed,FWM was minimum.The susceptibility of bilateral FGM,FWM,CA,GP,PU,TH,SN,RN,DN,PO,CC had no statistically significant differences(all P>0.05).The magnetic susceptibility in CA of different gender had statistically significant difference(P<0.05).Conclusion The brain magnetic susceptibility can be measured by QSM,and it can assess brain iron content quantitatively.更多还原