【摘要】 目的:优选乳癖消颗粒中三七和玄参的提取工艺。方法:以人参皂苷Rg₁、人参皂苷Rb₁和哈巴俄苷的转移率及干膏得率为综合评价指标,通过L₉（3⁴）正交试验考察溶剂量、乙醇浓度、提取时间及提取次数对乳癖消颗粒中三七、玄参醇提工艺的影响。采用HPLC法同时测定3种指标成分的含量。结果:最佳提取工艺为用8倍量60%的乙醇提取两次,每次2 h。人参皂苷Rg₁、人参皂苷Rb₁和哈巴俄苷的转移率分别为（79.48±1.561）%,（42.62±0.68）%和（44.89±0.58）%（n=3）,干膏得率（20.99±0.41）%。结论:该优选工艺稳定可行,可用于提取乳癖消颗粒中的三七和玄参。更多还原

【Abstract】 Objective: To optimize the extraction technology of Panax notoginseng and Scrophulariae radix from Rupixiao granule.Methods: With the dry extract rate and transfer rates of ginsenoside Rg₁,ginsenoside Rb₁ and harpagoside as the comprehensive index,the orthogonal design was adopted to investigate the effects of the amount and concentration of ethanol,extracting duration and times on the extraction technology. The contents of ginsenoside Rg₁,ginsenoside Rb₁ and harpagoside were determined by HPLC. Results: The optimal extraction technology was extracted twice with 8-fold amount of 60% ethanol with 2 h per time. The transfer rate of ginsenoside Rg₁,ginsenoside Rb₁ and harpagoside was（ 79. 4% ± 1. 56%）,（ 42. 62% ± 0. 68%） and（ 44. 89% ± 0. 58%）（ n = 3）,respectively. The dry extract rate was（ 20. 99% ± 0. 411%）. Conclusion: The optimized extraction technology is stable and feasible,which can be used for extracting Panax notoginseng and Scrophulariae radix from Rupixiao granule.更多还原