【摘要】 目的:考察苦参碱微乳水凝胶(MBH)的质量及其透皮性能,为苦参碱制剂的研发提供依据。方法:在4℃条件下放置3个月,考察MBH的稳定性,主要观察MBH粒子外观、黏度、pH、苦参碱含量等指标的变化。以小鼠离体皮肤为模型,采用双室渗透扩散装置考察MBH的经皮渗透情况。以家兔为实验对象,考察MBH对正常皮肤和受损皮肤的刺激性。结果:苦MBH在4℃条件下放置3个月后,其粒子外观、黏度、p H及苦参碱含量未发生明显变化。体外透皮实验表明,MBH对小鼠皮肤的渗透速率良好,单次或多次给药后无皮肤刺激性。结论:MBH具有良好的稳定性,透皮速率高,皮肤刺激性小,是一个具有开发应用前景的苦参碱经皮给药体系。更多还原

【Abstract】 Objective: To study the quality and transdermal properties of matrine microemulsion-based hydrogel( MBH) to provide basis for the development of the preparation. Methods: The stability of MBH was observed at 4 ℃ for 3 months and the changes of particle appearance,viscosity,p H and matrine content were observed. The transdermal permeation of MBH was investigated by a dual chamber permeation and diffusion device with excised mouse skin as the barrier. Taking rabbits as the experimental subjects,the irritation of MBH to the normal skin and damaged skin was investigated. Results: The appearance,viscosity,p H and matrine content of MBH at 4 ℃ in 3 months did not change significantly. In vitro transdermal test showed that MBH had a good penetration rate on mouse skin,and no skin irritation occurred after single or multiple administrations. Conclusion: MBH has good stability and high rate of transdermal penetration without skin irritation,which is a promising drug delivery system of matrine with good application prospects.更多还原