【摘要】 目的总结新鲜冰冻血浆在极低出生体重早产儿的临床疗效。方法 2013年1月至2015年11月临夏州人民医院新生儿科收治住院的早产儿162例。2013年1月至2014年1月的住院患儿72例为对照组;2014年2月至2015年11月的住院患儿90例为观察组。对照组给予维持血糖、预防感染、促肺成熟、合理的喂养等常规治疗;观察组在基础治疗的同时给予新鲜冰冻血浆静脉输注10~15mL/kg,3~7次。观察其发生感染、脏器出血、喂养不耐受、低血糖、多器官功能衰竭情况及光疗时间、住院时间、死亡率。结果观察组感染、脏器出血、喂养不耐受、低血糖、多器官功能衰竭发生率及死亡率均低于对照组,差异有统计学意义(P<0.05)。观察组光疗时间及住院时间均低于对照组,差异有统计学意义(P<0.05)。结论使用新鲜冰冻血浆治疗极低体重早产儿可减少脏器出血情况、感染、喂养不耐受、低血糖、多器官功能衰竭等的发生率。同时观察组患儿随访未见输血相关性传染病的发生,安全有效。更多还原

【Abstract】 Objective To summarize the clinical efficacy of fresh frozen plasma treatment for verylow-birth-weight infant.Methods A total of 162 cases of premature babies were included in the study,who were treated in Neonatology Departments of Linxia People’s Hospital between January 2013 and November2015.The 72 children who were hospitalized between Jan.2013 to Jan.2014 were chosen as the control group,and the 90 children from Feb.2014 to Nov.2015 as the observation group.The control group was given the treatment of maintaining blood sugar,preventing infection,promoting lung mature and feeding properly,while the observation group was treated by venous infusion of fresh frozen plasma,10~15mL/kg,3to7 times,in addition to the treatment for control group.Observe the incidence of infection,organ bleeding,feeding intolerance,hypoglycemia,multiple organ failure,phototherapy duration,length of hospital stay and the mortality.Results The incidence rate of infection,organ bleeding,feeding intolerance,hypoglycemia,multiple organ failure and the mortality in observation group was lower than that of the control group,and there was statistical difference(P<0.05).The phototherapy duration and length of hospital stay were shorter,compared with the control group,and the difference was statistically significant(P<0.05).Conclusion The use of fresh frozen plasma in the treatment of very-low-birth-weight premature infants can reduce the incidence of organ bleeding,infection,feeding intolerance,hypoglycemia,and multiple organ failure.At the same time,there is no transfusion related infectious disease in the observation group,so it is safe and effective.更多还原