【摘要】 目的:检测促血管生成素-2(Angiopoietin-2,Ang-2)和血管内皮生长因子(vascular endothelial growth factor,VEGF)在肾细胞癌患者外周血中的表达,探讨两者的变化及其相互关系。方法:收集56例肾细胞癌患者按肿瘤分期分为实验1、2、3组,30例健康人为对照组,采用ELISA方法分别检测标本Ang-2、VEGF的水平,对以上数据进行比较。结果:四组的VEGF两两比较,差异均有统计学意义(P<0.05);实验3组的Ang-2高于实验1组、实验2组、对照组,对照组的Ang-2低于实验1、2、3组,差异均有统计学意义(P<0.05)。肾细胞癌患者血清VEGF和Ang-2呈正相关(r=0.732,P<0.05)。结论:Ang-2、VEGF在肾细胞癌患者外周血中呈高表达,且与临床分期关系密切,Ang-2和VEGF在肾细胞癌血管生成中可能相互影响。更多还原

【Abstract】 Objective:To investigate the expression of angiopoietin-2 and vascular endothelial growth factor in peripheral blood of patients with renal cell carcinoma,and to explore the changes and their relationship.Method:56 renal cell carcinoma patients were selected,according to the tumor stage were divided into experimental group 1,2,3,30 healthy people were selected as the control group,specimens was detected by ELISA method Ang-2,the levels of VEGF,the above data were compared.Result:The differences between the four groups of VEGF compsred were statistically significant(P<0.05);the Ang-2 of experimental group 3 was higher than the experimental group 1,experimental group 2,control group,the Ang-2 of the control group was lower than the experimental group 1,2,3,the differences have the statistical significance(P<0.05).Serum VEGF and Ang-2 were positively correlated in patients with renal cell carcinoma(r=0.732,P<0.05).Conclusion:Ang-2 and VEGF are highly expressed in peripheral blood of patients with renal cell carcinoma and are closely related to clinical stages, and Ang-2 and VEGF may interact with each other in the angiogenesis of renal cell carcinoma.更多还原