【摘要】 目的:分析阿尔茨海默病(AD)患者血清S100B、抗脑抗体(ABAb)浓度变化及其与认知功能、生活能力间的关系,探讨S100B、ABAb在AD发病机制中可能的作用。方法:研究共纳入符合美国精神障碍诊断与统计手册第IV版(DSM-IV)AD诊断的患者32例(AD组),无认知障碍老年对照40例(对照组)。采用简易智能精神状态检查量表(MMSE)、日常生活能力量表(ADL)评估所有研究对象认知功能和生活能力,采用阿尔茨海默病评定量表认知分量表(ADAS-Cog)进一步评定AD患者的认知功能;应用酶联免疫吸附法(ELISA)检测血清S100B、ABAb浓度。结果:AD组血清S100B[(0.66±0.17)μg/L vs.(0.30±0.04)μg/L]、ABAb[(1.93±0.95)U/L vs.(1.31±0.25)U/L]浓度高于对照组(均P<0.01);AD组血清S100B浓度与MMSE总分负相关(r=-0.66),与ADAS-Cog总分、ADL评分呈正相关(r=0.57,r=0.53)(均P<0.005);血清ABAb浓度与MMSE总分呈负相关(r=-0.57),与ADAS-Cog总分、ADL评分呈正相关(r=0.52,r=0.34)(均P<0.05);AD组血清S100B与ABAb浓度正相关(r=0.51,P<0.005),在对照组中并未发现此相关关系(r=0.076,P>0.05)。结论:AD患者血清S100B、ABAb水平与认知损伤程度相关,提示S100B、ABAb可能在AD发病机制中起一定作用。更多还原

【Abstract】 Objective: To investigate the roles of S100 B protein and anti-brain antibody( ABAb) in the pathophysiology of Alzheimer’s disease( AD) by analyzing the changes of the serum levels of S100 B and ABAb and the relationships of the measures with cognition deficits in patients with AD. Methods: In this study,32 patients with AD( AD group) and 40 age-matched volunteers without cognitive impairment( control group) were enrolled. The diagnosis was made according to the Diagnostic and Statistical Manual of Mental Disorders,Fourth Edition( DSMIV). The mental and social functional conditions were assessed with the Mini-Mental State Examination( MMSE)and Activity of Daily Living Scale( ADL),the cognitive function of patients was evaluated with the Alzheimer’ s Disease Assessment Scale-cognitive subscale( ADAS-Cog). The serum S100 B proteinand ABAb levels were examined by enzyme-linked immuno sorbent assay( ELISA). Results: The serum S100 B protein[( 0. 66 ± 0. 17) μg/L vs.( 0. 30 ± 0. 04) μg/L] and ABAb [( 1. 93 ± 0. 95) U/L vs.( 1. 31 ± 0. 25) U/L]levels were higher in AD patients than in the controls( Ps < 0. 01). In AD patients,the serum S100 B protein markedly negatively correlated with the scores of the MMSE( r =-0. 66),while positively correlated with ADL and ADAS-Cog( r = 0. 57,r = 0. 53)( Ps< 0. 005). ABAb levels negatively correlated with the scores of the MMSE( r =-0. 57),while positively correlated with ADL and ADAS-Cog( r = 0. 52,r = 0. 34)( Ps < 0. 05). The serum S100 B protein levels were positively related to ABAb levels in AD group( r = 0. 51,P < 0. 005),but not in control group( r = 0. 076,P = 0. 654). Conclusions: It suggests that the serum levels of S100 B protein and ABAb are related with cognitive function in patients with Alzheimer’ s disease,and S100 B protein and ABAb might play key roles in mechanism of Alzheimer’ s disease.更多还原