【摘要】 目的探讨阿加曲班联合丁苯酞治疗进展性脑梗死的临床疗效。方法 60例进展性脑梗死患者,根据随机分配原则分为实验组与对照组,每组30例。两组患者均采用与脑循环及脑代谢相关的改善疗法,在此基础上,对照组给予阿加曲班治疗,实验组给予阿加曲班联合丁苯肽治疗。比较两组患者治疗前后美国国立卫生研究院卒中量表(NIHSS)评分、Barthel指数评分以及改良Rankin(m RS)评分。结果治疗前,两组患者NIHSS评分、Barthel指数评分、m RS评分比较差异无统计学意义(P>0.05)。治疗后,实验组NIHSS评分为(13.78±2.41)分,低于对照组的(15.38±2.97)分,差异具有统计学意义(P<0.05);实验组Barthel指数评分为(52.78±14.51)分,高于对照组的(42.38±16.17)分,差异具有统计学意义(P<0.05);实验组m RS评分为(2.61±0.36)分,低于对照组的(3.38±0.17)分,差异具有统计学意义(P<0.05)。结论采取阿加曲班联合丁苯肽对进展性脑梗死患者实施疗效,可以有效改善临床治疗,对于恢复神经功能有着显著作用,值得临床推广。更多还原

【Abstract】 Objective To discuss the clinical efficacy of argatroban combined with butylphthalide on the treatment of progressive cerebral infarction. Methods A total of 60 progressive cerebral infarction patients were randomly divided into experimental group and control group, with 30 cases in each group. Both groups received improved therapy associated with cerebral circulation and brain metabolism, and the control group also treated with argatroban. The experimental group was also treated with argatroban combined with butylphthalide. Comparison were made on National Institutes of Health Stroke scale(NIHSS) score, Barthel index score and modified Rankin(m RS) score before and after treatment between two groups. Results Before treatment, both groups had no statistically significant difference in NIHSS score, Barthel index score and m RS score(P>0.05). After treatment, the experimental group had lower NIHSS score as(13.78±2.41) points than(15.38±2.97) points in the control group, and their difference was statistically significant(P<0.05). The experimental group had higher Barthel index as(52.78±14.51) points than(42.38±16.17) points in the control group, and the difference was statistically significant(P<0.05). Both groups had no statistically significant difference in m RS score(P>0.05). After treatment, the experimental group had lower m RS score as(2.61±0.36) points than(3.38±0.17) points in the control group, and the difference was statistically significant(P<0.05). Conclusion Combination of argatroban and butylphthalide can effectively improve clinical efficacy of patients with progressive cerebral infarction and shows remarkable effect for recovery of nerve function, and it is worthy of clinical promotion.更多还原