【摘要】 目的对阿托伐他汀钙配合依折麦布药物治疗冠心病的效果与安全性进行探讨分析。方法 80例冠心病患者,按照治疗方式的不同分为观察组和对照组,各40例。对照组患者给予阿托伐他汀钙治疗,观察组患者给予阿托伐他汀钙配合依折麦布药物治疗。比较两组患者的治疗效果、血脂改善情况以及不良反应发生情况。结果观察组治疗总有效率为92.50%,高于对照组的75.00%,差异具有统计学意义(P<0.05)。治疗前两组血脂各项指标比较差异无统计学意义(P>0.05);治疗后两组血脂各项指标均得到显著改善,且观察组总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)改善程度显著优于对照组,差异具有统计学意义(P<0.05)。观察组不良反应发生率低于对照组,差异具有统计学意义(P<0.05)。结论临床治疗冠心病可采用阿托伐他汀钙配合依折麦布药物治疗,其能有效提高治疗效果,改善患者血脂水平,提高患者生活质量,且不良反应发生率低,具有较高的临床应用价值,值得在推广使用。更多还原

【Abstract】 Objective To investigate and analyze effect and safety by atorvastatin calcium combined with ezetimibe drug in the treatment of coronary heart disease. Methods A total of 80 coronary heart disease patients were divided by different treatment measures into observation group and control group, with 40 cases in each group. The control group received atorvastatin calcium for treatment, and the observation group received atorvastatin calcium combined with ezetimibe drug for treatment. Comparison was made on curative effect, blood lipid improvement and occurrence of adverse reactions between the two groups. Results The observation group had higher total effective rate in treatment as 92.50% than 75.00% in the control group, and the difference had statistical significance(P<0.05). Before treatment, the difference of blood lipid indexes had no statistical significance between the two groups(P>0.05). After treatment, both groups had obviously improved blood lipid indexes, and the observation group had much better improvement of total cholesterol(TC) and low density lipoprotein cholesterol(LDL-C) than the control group, and their difference had statistical significance(P<0.05). The observation group had lower incidence of adverse reactions than the control group, and their difference had statistical significance(P<0.05). Conclusion Implement of atorvastatin calcium combined with ezetimibe drug in clinical treatment of coronary heart disease can effectively improve curative effect, blood lipid level and quality of life in patients, along with low incidence of adverse reactions. This method contains high value for clinical application, and it is worth clinical promotion and application.更多还原