【摘要】 目的探讨冠心病合并妇科恶性肿瘤患者胃饥饿素(Ghrelin)/肥胖抑制素(obestatin)比值变化及临床意义。方法收集女性冠心病和妇科恶性肿瘤患者211例作为研究对象,根据检查结果分为冠心病肿瘤组(n=42)、单纯肿瘤组(n=55)、单纯冠心病组(n=64)及对照组(n=50)。采用ELISA法测定血清胃饥饿素、肥胖抑制素水平。根据冠状动脉造影结果采用Gensini积分评估冠状动脉病变程度。结果冠心病肿瘤组、单纯肿瘤组和单纯冠心病组患者的Ghrelin/obestatin比值显著低于对照组,差异均有统计学意义(P<0.05)。冠心病肿瘤组患者的Ghrelin/obestatin比值与Gensini积分呈负相关(r=-0.55,P<0.05)。结论冠心病合并妇科恶性肿瘤患者的Ghrelin/obestatin比值与冠状动脉病变程度密切相关。Ghrelin/obestatin比值在预测冠心病合并妇科恶性肿瘤中有一定的辅助参考价值。更多还原

【Abstract】 Objective To investigate the change and clinical significance of Ghrelin/obestatin in patients with coronary heart disease complicated with gynecology malignant tumor. Methods 211 cases of women patient with coronary heart disease and gynecological malignancies were collected as research subjects,and according to examination results,which were divided into coronary heart disease complicated with malignant tumor group( n = 42),simple malignant tumor group( n = 55),simple coronary heart disease group( n = 64),and control group( n = 50). Enzyme-linked immunosorbent assay( ELISA) method was used to determine serum Ghrelin and obestatin levels. Gensini score was used to evaluate the extent of coronary lesions according to the results of coronary angiography. Results The Ghrelin/obestatin ratio of coronary heart disease complicated with malignant tumor group,simple malignant tumor group and simple coronary heart disease group were significantly lower than the control group,and the differences were statistically significant( P < 0. 05). The Ghrelin/obestatin ratio of patients with coronary heart disease complicated with malignant tumor was negatively correlated with Gensini score( r =-0. 55,P < 0. 05). Conclusion Ghrelin/obestatin ratio is closely related to the degree of coronary artery disease in patients with coronary heart disease complicated with gynecology malignant tumor. Ghrelin/obestatin ratio has a supplementary reference value in predicting coronary heart disease combined with gynecology malignant tumor.更多还原