【摘要】 目的探究分析血清N端脑钠肽(NT-proBNP)对维持性血液透析患者血压、超滤量及容量负荷的诊断价值。方法随机选取我院在2013年1月-2014年1月期间收治的80例维持性血液透析患者为研究对象,根据超声检测下腔静脉直径/体表面积(VCD)将其分为VCD≥11.5mm·m-2高容量组(n=40)和VCD<11.5mm·m-2低容量组(n=40),动态观察两组患者血液透析前后的血压、超滤量及NT-proBNP水平变化情况。结果高容量患者的收缩压(157.32±18.05)mmHg、舒张压(95.82±13.07)mmHg显著高于低容量组(P<0.05),且高容量组患者的血清NT-proBNP水平(11837.02±1356.28)ng·L-1与低容量组(7683.29±1105.53)ng·L-1比较具有统计学意义;超滤量≥1.0kg的患者其血液透析前后的血清NT-proBNP水平(11472.38±1209.25)ng·L-1、(7148.43±1206.72)ng·L-1均显著高于超滤量<1.0kg的患者,两组比较具有统计学意义(P<0.05)。结论血液透析患者血清NTproBNP水平与血压、超滤量、容量负荷变化具有密切关系,通过检测血液透析患者的血清NT-proBNP水平能够及时准确评估血容量变化,有助于提供血液透析的安全性,具有积极的临床意义。更多还原

【Abstract】 Objective To explore serum N analysis period of brain natriuretic peptide(NT-proBNP)blood pressure in patients with maintenance hemodialysis,ultrafiltration volume,and the diagnostic value of load capacity.MethodsRandomly selected from our hospital in January 2013 to January 2014 80 cases admitted during the period of maintenance hemodialysis patients as the research object,according to the ultrasonic testing of inferior vena cava diameter(VCD)/body surface area will be divided into the VCD acuity 11.5mm,2m-high volume group(n=40)and VCD<11.5mm,m-2low volume group(n=40),dynamic observation of two groups of patients’ blood pressure before and after hemodialysis,ultrafiltration and the NT-proBNP level changes.Results The high capacity in patients with systolic blood pressure(157.32±18.05)mmHg,diastolic blood pressure(95.82±13.07)mmHg is significantly higher than the low volume group(P<0.05),and serum level of NT-proBNP in patients with high volume group(11837.02±1356.28)ng·L-1 and low capacity group(7683.29±1105.53)ng·L-1 is statistically significant;Ultrafiltration volume of 1.0kg or more before and after the hemodialysis patients with serum level of NT-proBNP(11472.38±1209.25)ng·L-1,(7148.43±1206.72)ng·L-1 were significantly higher than that of ultrafiltration quantity<1.0kg of patients,comparing the two groups have statistical significance(P<0.05).Conclusion The blood dialysis patients with blood pressure,serum levels of NT-proBNP ultrafiltration volume,capacity,load changes have close relations,through the detection of serum in patients receiving hemodialysis NT-proBNP level can accurately assess blood volume changes in time,help to provide the security of hemodialysis,have positive clinical significance.更多还原