【摘要】 目的研究血清缺血修饰白蛋白(IMA)在急性心肌梗死(AMI)早期诊断中的临床价值。方法分别检测非心源性胸痛组(FXY组,n=37)、非AMI组(n=42)和AMI组(n=46)患者在胸痛发作2h内、2h-4h、4h-6h、6h-12h、12h-24h的血清IMA、cTnI、CK、CK-MB水平。结果 AMI组在胸痛发作2h内的患者血清IMA显著高于非AMI组和FXY组(P<0.05),而cTnI、CK和CK-MB无统计学差异(P>0.05);AMI患者中,血清IMA在胸痛发作早期的阳性检出率(93.48%,76.09%)显著高于同时段的cTnI(13.04%,65.22%)、CK(2.17%,23.91%)和CK-MB(2.17%,15.22%),差异有统计学意义(P<0.05)。结论血清缺血修饰白蛋白是早期诊断心肌梗死的敏感指标,对于心肌梗死的早期诊断、病情判断、及早治疗和避免误诊都有重要的临床价值。更多还原

【Abstract】 Objective Discuss the value of serum ischemia modified albumin(IMA)in early diagnosis of acute myocardial infarction(AMI).Methods Detected the serum concentrations of IMA,cTnI,CK,CKMB from the patients of non-cardiac chest pain group(n=37),non AMI group(n=42)and AMI group(n=46)in less than 2h,2hto 4h,4hto6 h,6hto 12 h,12hto 24 htime periods.Results In the periods of the onset of chest pain to 2h,serum IMA concentrations of AMI group were significantly higher than that of non AMI group and FXY group(P<0.05),and the difference of cTnI,CK and CK-MB were no statistically significant(P>0.05);in the early onset of chest pain period,the diagnostic positive rates of IMA(93.48%,76.09%)were significantly higher than that of cTnI(13.04%,65.22%),CK(2.17%,23.91%)and CK-MB(2.17%,15.22%),P<0.05.Conclusion IMA is a sensitive index for early diagnosis of acute myocardial ischemia injury of AMI,the predictive value of the diagnosis of myocardial ischemia myocardial damage than the traditional flag high,the changes of the serum levels can provide a reliable basis for AMI differential diagnosis,disease treatment and development.更多还原