【摘要】 为确定丁香叶黄酮的保肝作用,将小鼠随机分为5组,即对照组、模型组、丁香叶黄酮高剂量组(40 mg/kg体重)、中剂量组(35 mg/kg体重)、低剂量组(30 mg/kg体重),以血清转氨酶(ALT、AST)、肝组织指标(MDA、NO、SOD、GSH、GSH-Px)及II相药物代谢酶GSTA1为检测对象,结合小鼠肝脏病理变化综合分析。结果显示,丁香叶黄酮高剂量组血清转氨酶和肝组织中MDA、NO均极显著降低(P<0.01),SOD、GSH、GSH-Px均极显著升高(P<0.01),GSTA1的含量也极显著升高(P<0.01);肝脏组织病理学显示脂肪变性、坏死及炎性细胞浸润减轻;而中、低剂量组的各指标和组织学变化均不如高剂量组明显。研究表明,丁香叶黄酮以40 mg/kg体重剂量对小鼠药物性肝损伤有较好的保护作用。更多还原

【Abstract】 To determine the protective effect of flavonoids on folium syringae,mice were randomly divided into 5 groups including control,model,folium syringae high,middle and low dose groups.Serum transaminases(ALT,AST),liver index(MDA,NO,SOD,GSH,GSH-Px) and GSTA1 were analyzed as detection indicators,and tissues were also collected for histopathology.The results showed that serum transaminases,MDA and NO were significantly reduced(P < 0.01),and SOD,GSH,GSH-Px and GSTAI were significantly increased(P < 0.01).In addition hepatic tissue,fat degeneration,necrosis and inflammatory cell infiltration were reduced in high dose group,while all the changes were less in middle and low dose groups.These results suggest that the folium syringae flavonoids has a protective effect on mice from drug hepatic injury at 40 mg/kg dose.更多还原