【摘要】 基于中医脉诊原理,研究人体各器官流阻变化对血流动力学参数的影响。建立人体血液体循环流体网络模型,采用10次谐波血流动力学表达式模拟心脏输出。改变各器官流阻,流阻比η分别取值0.5、1.0、1.5、2.0、2.5、3.0,利用平均法求解模型。假设心输出量一定,结果表明:随着流阻增大对应分支流量下降;不同分支流阻增大均能使主动脉平均压力上升,当流阻比η=3.0时,脑、肝、肾、胃、肠、脾分支流阻增大引起主动脉压力较正常值分别增大23.29%、16.42%、14.67%、9.69%、9.59%、7.82%;肝和肾分支流阻变化对桡动脉影响较大,当流阻比η=3.0时,桡动脉压力较正常值分别增大22.85%和11.17%,而其他器官分支流阻变化对桡动脉影响很小;对于桡动脉压力谐波振幅,脑分支流阻变化的影响最大,其次是肝和肾,而胃肠脾的影响很小。可见,该模拟研究方法可以得到人体血流动力学参数与各器官流阻变化之间的理论联系,为中医脉诊提供一些理论依据。更多还原

【Abstract】 Hemodynamic parameters will be studied under the changes of different organs flow resistances,based on the principles of traditional Chinese medicine pulse diagnosis. A fluid network model of systemic circulation of human blood is established. Utilizing a 10 times harmonic hemodynamics expression of cardiac output and the average method of adaptive control,the model is solved when η is respectively set to 0. 5,1. 0,1. 5,2. 0,2. 5 and 3. 0. With the cardiac index keeping constant,the results show that the average flow rate decreases with the increase of flow resistance of corresponding branch. The aortic mean pressure increases with the rise of flow resistance of organ branch. When η is setted to 3. 0,the aortic mean pressure increases 23. 29%,16. 42%,14. 67%,9. 69%,9. 59% and 7. 82% higher than normal by the flow resistance increase of brain,liver,kidney,stomach,intestine and spleen branch respectively. The flow resistance of liver and kidney branch has the great effect on the radial artery mean pressure,which respectively increases 22. 85% and 11. 17% when η is setted to 3. 0. While the other organ branches have less influence. For the harmonic amplitude of the radial artery pressure,the biggest affecting factor is the brain branch flow. The liver and kidney branch have less influence than the brain. The stomach,intestine and spleen branch have little impact on it. In this paper,we have found the relationships between the hemodynamic parameters and the changes of different organs flow resistances by the simulation method,and it can provide some theoretical basis for traditional Chinese medicine pulse diagnosis.更多还原