【摘要】 目的应用动态血糖监测系统(CGMS)观察住院2型糖尿病患者低血糖的发生率及临床特征。方法 80例2型糖尿病患者,按有无低血糖事件分为无低血糖组(61例)和低血糖组(19例)。采用CGMS连续3 d监测血糖变化。观察两组临床指标。结果 19例(23.8%)患者发生低血糖,0:00~03:00是低血糖的高发时间段。低血糖组血肌酐水平为(105.10±0.76)μmol/L,高于无低血糖组的(89.10±0.71)μmol/L,空腹C肽(FCP)为(0.67±1.62)ng/ml,餐后2 h C肽(2 h CP)为(1.16±1.93)ng/ml,低于无低血糖组的(0.83±1.47)、(1.83±1.01)ng/ml,差异具有统计学意义(P<0.05)。使用三餐前速效胰岛素+长效胰岛素治疗患者低血糖发生率最高(36.8%),口服非胰岛素促泌剂治疗患者无低血糖发生。结论住院2型糖尿病患者中老年人低血糖发生率高,应加强夜间血糖监测,应用CGMS可为治疗方案提供参考依据。更多还原

【Abstract】 Objective To observe the incidence of hypoglycemia and clinical characteristics of hypoglycemia in hospitalized type 2 diabetes mellitus patients by applying continuous glucose monitoring system(CGMS). Methods A total of 80 type 2 diabetes mellitus patients using CGMS blood glucose monitoring system were divided by presence or absence of hypoglycemia into non-hypoglycemia group(61 cases) and hypoglycemia group(19 cases). Blood glucose changes were monitored for 3 consecutive days, and clinical indicators of the two groups were observed. Results Hypoglycemia occurred in 19 patients(23.8%), and 0:00 ~ 03:00 was the high period of hypoglycemia. The hypoglycemia group had higher serum creatinine level as(105.10±0.76) μmol/L than(89.10±0.71) μmol/L in non-hypoglycemia group, lower fasting C peptide(FCP) as(0.67±1.62) ng/ml, postprandial 2 h C peptide(2 h CP) as(1.16±1.93) ng/ml than(0.83±1.47) mmol/L and(1.83±1.01)ng/ml. Their difference was statistically significant(P<0.05). The incidence of hypoglycemia was highest(36.8%) in patients treated with fast insulin and long-acting insulin before three meals, and no hypoglycemia was present in patients treated with oral non-insulin secretagogues. Conclusion The incidence of hypoglycemia in middle-aged and elderly patients with type 2 diabetes mellitus is high, and blood glucose monitoring should be strengthened. Application of CGMS can provide reference for treatment regimen.更多还原