【摘要】 目的提高临床医师对马尔尼菲青霉感染合并卡氏肺孢子菌肺炎的认识及诊断水平。方法对1例青年男性患者马尔尼菲青霉感染合并卡氏肺孢子菌肺炎的诊疗经过进行分析、讨论并复习中外文献。结果咽喉部马尔尼菲青霉感染通过咽喉部专科检查、痰培养找到马尔尼菲青霉生长,病理活检证实;卡氏肺孢子菌肺炎通过胸部CT征象及卡氏肺孢子菌(PC)聚合酶链反应(PCR)阳性确诊。马尔尼菲青霉感染合并PCP治疗选用伊曲康唑、SMZ/TMP同时口服碳酸氢钠,疗效满意。结论对反复咽喉部溃疡难以愈合的患者建议痰培养、局部组织活检及肺部影像学检查,尽早明确诊断,恰当治疗。更多还原

【Abstract】 In order to increase awareness of infection of Penicillium marneffei combined with Pneumocystis carinii pneumonia,we analysed and discussed the diagnosis and treatment of a P.marneffei combined with Pneumocystis carinii pneumonia and reviewed relevant literaure.Pharynx and larynx P.marneffei infection uozhes logy and molecullar was confirmed by physical examination,sputum culture and biopsy.Pneumocystis carinii pneumonia was diagnosed by CT findings and tested positive by PCR for P.carinii(PC).After antifungal treatment,the patient’s symptoms and signs showed significant improvement.In conclusion,to achieve early diagnosis and appropriate treatment,sputum culture,biopsy and chest radiograph are suggested for pharynx and larynx recurrent ulcer which is difficult to heal.更多还原