【摘要】 链霉菌产生两类重要的抗肿瘤药物阿霉素和柔红霉素,链霉菌通过ABC家族的DrrAB外排泵将这两种抗生素运输到细胞外。本文对DrrAB外排系统的结构,DrrA和DrrB蛋白的表达与相互作用以及该复合物的装配和多药外排功能的研究进展做一简要综述。更多还原

【Abstract】 The bacterium Streptomyces peucetius produces doxorubicin and daunorubicin,and the two widely used anticancer antibiotics.Two open reading frames,drrA and drrB,were proposed to encode for an ABC(ATP-binding cassette)type of permease that carries out export of the antibiotic ABC(ATP binding cassette)-type transporter for the exportation of these two antibiotics.In this paper,the structure,expression and interaction of DrrA and DrrB protein and the research progress of the assembly and multi drug efflux function of DrrAB are briefly reviewed.更多还原