【摘要】 目的 探讨急性心肌梗死(AMI)急诊PCI术后应用左卡尼汀,对血清心型脂肪酸结合蛋白(H-FABP)及近期预后的影响。方法 选择AMI行急诊PCI患者102例,随机分为治疗组54例和对照组48例,实验组在急诊PCI中加用左卡尼汀3.0 g+0.9%生理盐水250 mL静脉滴注,以后每日1次,连续7d以上。对照组行急诊PCI治疗及常规药物治疗。比较两组血浆H-FABP、CK-MB、cTnI水平和住院期间LVEF值,随访90 d后六分钟步行试验(6MWT)距离。结果实验组术后血浆H-FABP、CK-MB、cTnI水平较对照组明显降低,LVEF高于对照组(P<0.05),随访90 d后实验组6MWT距离明显高于对照组(P<0.05)。结论 AMI急诊PCI患者补充左卡尼汀对缺血心肌细胞有保护作用,可明显改善患者的心功能。更多还原

【Abstract】 Objective To explore the effect of L-carnitine on content of heart fatty acid binding protein( H-FABP) and the influence on the recent prognosis in acute myocardial infarction(AMI) patients with emergent PCI. Methods A total of 102 AMI patients with PCI were randomly divided into two groups, one was routine treatment group : treated with routine therapy; another was L-carnitine treatment group : treated with L-carnitine every day on the basis of above routine treatment.H-FABP, CK-MB. cTnI concentrations, LVEF and 6-minute walk test(6 MWT) were compared between the two groups. Results The difference of plasma heart-type fatty acid-binding proteins(H-FABP), creatine kinase isoenzyme(CK-MB), cardiac troponin I(cTnI)level and left ventricle ejection fraction( LVEF) was statistically significant( P <0. 05) in two groups. Walking distance evaluated by 6 MWT was significantly higher in L-carnitine treatment group after three months of follow-up. Conclusion L-carnitine shows protective effect against the ischemia injury in cardiomyocytes and improves cardiac function for the emergency PCI patients with ST-elevation myocardial infarction.更多还原