【摘要】 目的评估超重或肥胖和胆管癌发病之间的关系。方法:通过检索Pub Med、Cochrane、Embase、中国生物医学文献数据库(CBM),纳入研究肥胖与胆管癌发病风险的文章进行Meta分析。结果 16研究符合纳入标准,其中包括5个队列和11个病例对照研究。与正常体重相比,体重超重(合并OR:1.20,95%CI:1.07~1.34)、肥胖(合并OR:1.66,95%CI:1.31~2.11)和过重(合并OR:1.33,95%CI:1.18~1.49)与胆管癌发病均显著相关。漏斗图显示无发表偏倚的证据。结论:肥胖增加胆管癌的发病风险增加,还需要长期的队列研究进一步证实。更多还原

【Abstract】 Objective To assess the association between overweight or obesity and the incidence of cholangiocarcinoma.Methods Using Pub Med,Cochrane,EMBase and CBM databases,studies were included if they reported cholangiocarcinoma with respect to obesity or overweight.Results Sixteen studies met the inclusion criteria,which included five cohort and eleven case-control studies.Compared with normal weight,being overweight(pooled OR:1.20,95% CI:1.07-1.34),obesity(pooled OR:1.66,95% CI:1.31-2.11),and excess body weight(pooled OR:1.33,95% CI:1.18-1.49) were significantly associated with cholangiocarcinoma.The funnel plot revealed no evidence for publication bias.Conclusion Obesity is associated with the increased risk of cholangiocarcinoma,which needs to be confirmed by long-term cohort studies.更多还原