【摘要】 目的观察硬膜外麻醉下开腹胆囊切除术中给予右美托咪定的临床效果。方法选择100例开腹胆囊切除术患者,ASAⅠ-Ⅱ,随机分为右美托咪定组(A组)和对照组(B组),每组为50例患者。A组(右美托咪定组)在硬膜外麻醉后待平面固定后缓慢静脉泵注1 ug/kg右美托咪定,静脉泵注时间维持15分钟。B组(对照组)在硬膜外麻醉后静脉给予1 ug/kg的芬太尼。结果 A组术后镇痛效果优于B组(P<0.05),B组在术中舌后坠和呼吸抑制明显高于A组(P<0.05)。结论静脉注射右美托咪定产生一定的镇静镇痛作用,显著降低术后疼痛患者的比例,术后镇痛时效延长,且无呼吸抑制。更多还原

【Abstract】 Objective To observe clinical effect of dexmedetomidine in open cholecystectomy under epidural anesthesia. Methods Choose 100 cases open cholecystectomy patients with ASA Ⅰ and Ⅱ, divide them into dexmedetomidine group(group A) and control group(group B) randomly, 50 cases in each. Group A(dexmedetomidine group) was treated with Slow intravenous injection 1 ug/kg dexmedetomidine after epidural anesthesia with plane fixation for 15 minutes. B group(control group) with intravenous injection 1 ug/kg fentanyl after epidural anaesthesia. ResultsPostoperative analgesia effect of group A was better than group B(P<0.05), intraoperative glossocoma and respiratory inhibition of B group was significantly higher than group A(P<0.05). Conclusion Intravenous dexmedetomidine has certain sedative and analgesic effect, can reduce proportion of postoperative pain significantly, prolong postoperative analgesia effect, and has no respiratory depression.更多还原