【摘要】 T细胞免疫球蛋白黏蛋白分子(Tim)基因家族于2001年被发现,目前发现的人类Tim基因包括:Tim-1、Tim-3和Tim-4。Tim-3是Tim家族最重要的成员之一,在女性生殖系统疾病的发生、发展中起着双重调节作用。在卵巢癌、宫颈癌患者体内,Tim-3表达显著增高,其表达程度与癌症进展和转移有关。正常妊娠期间,母胎界面固有免疫细胞Tim-3表达量上调,阻断Tim-3表达,则可导致妊娠物丢失;而自然流产孕妇特异性免疫细胞Tim-3表达量,则较正常妊娠孕妇增加。另外,Tim-3异常表达与子痫前期、胚胎反复移植失败及女性生殖系统感染等有关。进一步探索Tim-3的致病机制,将为女性生殖系统疾病的干预治疗,提供更多途径与靶点。更多还原

【Abstract】 T-cell immunoglobulin mucin(Tim)gene family was found in 2001,Tim-1,Tim-3and Tim-4 genes are included in human Tim genes family.Tim-3is one of the most important members in Tim family. Accumulated evidence shows that Tim-3 plays dual roles in female reproductive system that negatively or positively regulate its immune cells.Tim-3is expressed highly in ovarian cancer and cervical cancer,and it is related with the increased degree of malignancy of cancer.During normal pregnancy,Tim-3is strikingly up-regulated in innate immune cells at the maternal-fetal interface,however,adaptive immune cells express higher level of Tim-3in spontaneous abortion pregnancy than in normal pregnancy.In addition,the abnormal express of Tim-3has relation with preeclampsia,repeated embryo transplantation failure and infection of female reproductive system.The dual regulation mechanism of Tim-3should be further studied,which will provide a intervening measure and therapeutic approach for the female reproductive system disease.更多还原