【摘要】 目的对我国现有涉及质子泵抑制剂(PPI)临床实践指南进行梳理,了解目前国内PPI在不同病种中的应用概况,为规范PPI用药提供重要参考。方法检索国内含PPI用药的临床实践指南,并从指南的类别、PPI有效性和安全性的证据水平、指南推荐强度等角度进行整理归纳。结果纳入含PPI用药的临床实践指南17份,大部分指南没有基于循证证据进行制定,仅5份(29.4%)提及应用循证的方法制定指南,主要涉及胃肠道用药方面。结论 PPI临床用药实践指南存在诸多不明确的推荐意见,导致临床PPI用药较为混乱,亟待制定相关规定以进一步规范PPI用药。更多还原

【Abstract】 OBJECTIVE To know about the application of proton pump inhibitors( PPI) in different diseases and provide the essential references for the use of PPI,clinical practice guidelines for PPI in China were sort out and analyzed. METHODS The clinical practice guidelines of PPI were searched and sort out according to the categories,levels of evidence of effectiveness and safety,strength of recommendations of guidelines,and so on. RESULTS Seventeen clinical practice guidelines,which are related to the prevention and cure in gastrointestinal disease,were included in our researches. Except five guidelines,the rest of them were not evidence-based clinical guidelines. CONCLUSION The recommendations of the clinical practice guideline for PPI are not just very clear,which lead to disorder of PPI clinical medication,the urgent need is to develop relevant provisions to further regulate the PPI medication.更多还原