【摘要】 目的研究长春花(Catharanthus roseus)中的化学成分。方法采用反复硅胶、Rp-18、Sephadex LH-20等多种柱色谱对长春花体积分数95%乙醇提取物进行分离纯化,根据理化常数和波谱数据对化合物进行结构鉴定。结果从长春花中分离鉴定了22个化合物,分别为熊果酸(1),胡萝卜苷(2),四氢鸭脚木碱(3),7α-羟基-β-谷甾醇(4),文多灵(5),β-谷甾醇(6),aurantiamide acetate(7),洛柯定碱(8),齐墩果酸(9),阿吗碱(10),(22E,24R)麦角甾-7,22-二烯-3β,5α,6β-三醇(11),白桦脂酸(12),豆甾醇(13),槲皮素(14),山柰酚(15),文多尼定碱(16),长春质碱(17),异橙黄胡椒酰胺乙酸脂(18),利血平(19),panarine(20),蛇根碱(21)和16R-E-isositsirikine(22)。结论化合物4,7,11,13,18,20为首次从该植物中分离得到。更多还原

【Abstract】 OBJECTIVE To study the chemical constituents of Catharanthus roseus. METHODS Various column chromatograghic methods on silica gel,Rp-18,and Sephadex LH-20 were applied for the isolation and purification of the 95% ethanol extract.The structures were elucidated by their physicochemical properties and spectral data. RESULTS Twenty-two compounds were obtained and identified as ursolic acid(1),daucesterol(2),tetrahydroalstonine(3),7α-hydroxy-β-sitosterol(4),vindoline(5),β-sitosterol(6),aurantiamide acetate(7),lochnericine(8),oleanolic acid(9),ajmalicine(10),(22E,24R)-ergosta-7,22-dien-3β,5α,6β-triol(11),betulinic acid(12),stigmasterol(13),quercetin(14),keampferol(15),vindorosine(16),catharanthine(17),diaaurantiamide acetate(18),reserpine(19),panarine(20),serpentine(21),and 16R-E-isositsirikine(22). CONCLUSION Compounds 4,7,11,13,18,and 20 are isolated from C.roseus for the first time.更多还原