【摘要】 巨噬细胞主要来源于骨髓前体细胞,在机体固有免疫应答和适应性免疫应答中发挥极其重要的作用,与炎性反应、免疫防御、血管形成、肿瘤的形成以及内环境稳定等密切相关。在不同的微环境中,巨噬细胞可以分化为不同细胞亚群:M1型,即经典活化巨噬细胞;M2型,即替代活化巨噬细胞。2种不同表型的巨噬细胞在不同疾病中也发挥着不同的作用,M1型主要分泌各种炎性因子促进炎性反应;而M2型主要参与抗炎反应、促进组织修复等。本文对巨噬细胞极化的研究进展进行综述。更多还原

【Abstract】 Macrophages mainly derive from bone marrow precursor cells and play an important role in innate and adaptive immune response; they are associated with multiple biological activities such as inflammation,immune defense, angiogenesis, tumor formation and homeostasis. Macrophages can differentiate into different cell subsets in different microenvironments; M1 are classic activated macrophages; M2 are alternative activated macrophages. M1 macrophages mainly secrete inflammatory factors to promote inflammation; M2 macrophages are involved in anti-inflammatory response.and tissue repair. This paper reviewed research progress of macrophage polarization.更多还原