Macrophages mainly derive from bone marrow precursor cells and play an important role in innate and adaptive immune response; they are associated with multiple biological activities such as inflammation,immune defense, angiogenesis, tumor formation and homeostasis. Macrophages can differentiate into different cell subsets in different microenvironments; M1 are classic activated macrophages; M2 are alternative activated macrophages. M1 macrophages mainly secrete inflammatory factors to promote inflammation; ...