【摘要】 目的 探讨孕前使用口服避孕药(OCp)对儿童哮喘和过敏性鼻炎发生风险的影响。方法 回顾性分析2008年1月至2010年12月于延安大学附属医院产检并分娩的800例孕产妇临床资料。根据孕前是否使用OCP将所有患者分成对照组(无使用OCP史,662例)和观察组(有使用OCP史,138例),并将观察组分成A组(孕前使用OCP<3个月,76例)和B组(孕前使用OCP≥3个月,62例)。比较孕产妇分娩的儿童哮喘和过敏性鼻炎发生情况,并采用Logistic回归方法分析孕前使用OCP对儿童哮喘和过敏性鼻炎发生风险的影响。结果 观察组孕产妇分娩的儿童哮喘和过敏性鼻炎发生率明显高于对照组[19.6%(27/138)比9.2%(61/662)、25.4%(35/138)比9.8%(65/662)],差异均有统计学意义(均P<0.05)。B组孕产妇分娩的儿童哮喘和过敏性鼻炎发生率明显高于A组[27.4%(17/62)比13.2%(10/76)、33.9%(21/62)比18.4%(14/76)],差异均有统计学意义(均P<0.05)。Logistic回归方法分析结果显示,孕前使用OCP明显影响儿童哮喘(P=0.031)和过敏性鼻炎(P<0.001)的发生风险;孕前使用OCP史≥3个月对儿童哮喘(P=0.030)和过敏性鼻炎(P=0.008)发生风险的影响更为明显。结论 孕前使用OCP明显影响儿童哮喘和过敏性鼻炎的发生风险,尤其是长期服用。更多还原

【Abstract】 Objective To investigate the effects of pre-pregnancy oral contraceptives( OCP) on occurrences of asthma and allergic rhinitis in children. Methods Totally 800 pregnant women who had prenatal examination in Yan’an University Affiliated Hospital from January 2008 to December 2010 were retrospectively analyzed; 138 women who had taken OCP before pregnancy were enrolled in observation group; 662 women without pre-pregnancy OCP history were enrolled in control group. The observation group was divided into pre-pregnancy OCP history < 3 months group( group A, 76 cases) and pre-pregnancy OCP history ≥ 3 months group( group B,62 cases). General clinical information and occurrences of asthma and allergic rhinitis in children were analyzed.Effects of pre-pregnancy OCP on childhood asthma and allergic rhinitis were analyzed by logistic analysis.Results Incidences of childhood asthma and allergic rhinitis in observation group were significantly higher than those in control group [ 19. 6%( 27/138) vs 9. 2%(61/662), 25. 4%( 35/138) vs 9. 8%(65/662)](P <0. 05). Incidences of childhood asthma and allergic rhinitis in group B were significantly higher than those in group A[27.4%(17/62) vs 13. 2%(10/76), 33.9%(21/62) vs 18. 4%(14/76) ](P < 0. 05). Logistic regression analysis showed that pre-pregnancy OCP had effects on the occurrences of asthma(P =0.031) and allergic rhinitis(P< 0.001) in children; pre-pregnancy OCP history ≥ 3 months had significant effects on the occurrences of asthma(P = 0. 030)and allergic rhinitis( P = 0. 008) in children. Conclusion Pre-pregnancy OCP significantly increases the risk of childhood asthma and allergic rhinitis, especially in pregnant women with a long duration of pre-pregnancy OCP history.更多还原