【摘要】 目的 分析布地奈德联合特布他林对哮喘急性期的治疗效果。方法 选取2014年3月至2015年3月内蒙古自治区包头市中心医院收治的100例急性期哮喘患者,按照随机数字表法分为对照组与观察组,各50例。对照组予以特布他林治疗,观察组在对照组基础上联合布地奈德治疗。比较2组治疗前后免疫球蛋白（Ig,包括IgG、IgM、IgE、总IgE）水平、T细胞亚群（包括CD₃⁺、CD₄⁺、CD₈⁺及CD₄⁺/CD₈⁺比值）、嗜酸粒细胞（EOS）计数、肺功能指标[包括最大呼气流量（PEF）及第1秒用力呼气容积（FEV₁）]变化。比较2组疗效及不良反应发生情况。结果 治疗后,观察组IgG、IgM高于对照组[（11.3±2.3）g/L比（9.9±2.3）g/L、（2.43±0.60）g/L比（1.95±0.53）g/L],IgE、总IgE低于对照组[（202±59）g/L比（244±62）g/L、（76±9）kIU/L比（154±10）kIU/L];CD₃⁺、CD₄⁺和CD₄⁺/CD₈⁺比值高于对照组[（69±8）%比（64±8）%、（41±6）%比（38±7）%、（1.60±0.19）比（1.46±0.16）],CD₈⁺低于对照组[（29±3）%比（31±3）%];EOS计数低于对照组[（0.41±0.08）×10⁹/L比（0.58±0.11）×10⁹/L];PEF和FEV₁高于对照组[（5.8±1.3）L/s比（5.2±1.2）L/s、（4.4±0.8）L比（3.8±0.7）L],差异均有统计学意义（均P<0.05）。观察组治疗有效率高于对照组[96.0%（48/50）比84.0%（42/50）],差异有统计学意义（P<0.05）。治疗期间2组患者均未发现明显不良反应。结论 布地奈德联合特布他林治疗哮喘急性期的效果确切,能够有效改善患者的肺功能并提高机体的免疫能力。更多还原

【Abstract】 Objective To analyze the curative effect of budesonide combined with terbutaline on acute asthma.Methods One hundred patients with acute asthma from March 2014 to March 2015 in Baotou Central Hospital in Inner Mongolia Autonomous Region were randomly divided into control group and observation group,with 50 cases in each group.The control group had terbutaline;the observation group had budesonide and terbutaline.Immunoglobulin（Ig,including IgG,IgM,IgE,total IgE）,T cell subgroups（including CD₃⁺,CD₄⁺,CD₈⁺,CD₄⁺/CD₈^*）,eosinophil count,pulmonary function indexes[including peak expiratory flow（PEF） and forced expiratory volume in 1 second（FEV₁）]and adverse reactions were analyzed.Results After treatment,IgG and IgM in observation group were higher than those in control group[（11.3 ±2.3）g/L vs（9.9 ±2.3）g/L,（2.43 ±0.60）g/L vs（1.95 ±0.53）g/L];IgE and total IgE in observation group were lower than those in control group[（202±59）g/L vs（244±62）g/L,（76 ±9）kIU/L vs（154 ± 10） kIU/L];CD₃⁺,CD₄⁺ and CD₄⁺/CD₈⁺ in observation group were higher than those in control group[（69 ±8）%vs（64±8）%,（41 ±6）%vs（38 ± 7）%,（1.60 ±0.19） vs（1.46 ±0.16）];CD₈⁺ in observation group was lower than that in control group[（29 ±3）%vs（31 ±3）%];EOS count in observation group was lower than that in control group[（0.41 ± 0.08） × 10⁹/L vs（0.58 ±0.11） × 10⁹/L];PEF and FEV₁ in observation group were higher than those in control group[（5.8 ±1.3）L/s vs（5.2±1.2）L/s,（4.4 ±0.8）L vs（3.8 ±0.7）L];the differences were statistically significant（P<0.05）.The effective rate in observation group was higher than that in control group[96.0%（48/50） vs 84.0%（42/50）],the difference was statistically significant（P <0.05）.No severe adverse reaction was observed during treatment in both groups.Conclusion Budesonide combined with terbutaline is effective for acute asthma and can improve pulmonary function and body immunity.更多还原