【摘要】 目的:探讨氨溴索治疗小儿呼吸系统疾病的最佳给药途径。方法:选择2014年6月-2016年6月我院儿科收治的呼吸系统疾病患儿120例,按就诊单双号顺序分为静脉滴注组和雾化吸入组,各60例。在常规治疗基础上,静脉滴注组患儿给予盐酸氨溴索注射液7.5 mg溶入50 m L 5%葡萄糖注射液中,ivgtt,bid;雾化吸入组患儿雾化吸入盐酸氨溴索注射液7.5 mg,每次吸入15min,bid。两组患儿均治疗7 d。比较两组患儿的临床疗效,氧分压[p（O₂）]、二氧化碳分压[p（CO₂）]、吸痰次数、临床指标和不良反应发生情况。结果:雾化吸入组患儿的总有效率（96.67%）显著高于静脉滴注组（78.33%）,p（O₂）水平显著高于静脉滴注组,吸痰次数显著少于静脉滴注组,发热消失时间、气喘消失时间、氧疗时间、肺部啰音消失时间、咳嗽消失时间和平均住院时间均显著短于静脉滴注组,差异均有统计学意义（P<0.05）。两组患儿的p（CO₂）水平和不良反应发生率比较,差异均无统计学意义（P>0.05）。结论:氨溴索能有效治疗小儿呼吸系统疾病,且雾化吸入的临床疗效优于静脉滴注。更多还原

【Abstract】 OBJECTIVE:To investigate the optimal administration route of ambroxol in the treatment of pediatric respiratory disease.METHODS:Totally 120 children with respiratory disease in pediatric department of our hospital during Jun.2014-Jun.2016 were divided into intravenous dripping group and atomization inhalation group according to even and odd-numbered admission order,with 60 cases in each group.Intravenous drip group was given Ambroxol hydrochloride injection 7.5 mg dissolved in 5%glucose solution 50 m L,ivgtt,bid;aerosol inhalation group was given aerosol inhalation of Ambroxol hydrochloride injection 7.5mg,for 15 min each time,bid.The two groups were treated with 7 d.Clinical efficacies,p（O₂）and p（CO₂）level,the times of sputum absorption,clinical indexes and the occurrence of ADR were compared between 2 groups.RESULTS:Total response rate of atomization inhalation group（96.67%）was significantly higher than intravenous dripping group（78.33%）;p（O₂）level was significantly higher than intravenous dripping group,while the times of sputum absorption,fever disappearance time,asthma disappearance time,oxygen therapy time,pulmonary rales disappearance time,cough disappearance time and average hospitalization time were significantly less or shorter intravenous dripping group,with statistical significance（P<0.05）.There was no statistical significance in p（CO₂）level and the incidence of ADR between 2 groups（P>0.05）.CONCLUSIONS:Ambroxol is effective in the treatment of pediatric respiratory disease,and clinical efficacy of atomization inhalation is better than intravenous drop.更多还原