【摘要】 目的:为补充和完善我国基本药物遴选方法提供参考。方法:针对基本药物遴选的要求,运用背包理论,结合实际情况确定基本药物遴选的目标函数和约束条件,进行基本药物遴选模型的构建,并通过实例分析所建模型的可行性。结果:所构建的模型目标函数为所遴选基本药物组合的成本最小值,即Min∑C_jX_j,其他还包括药品的疾病覆盖、药品不良反应、禁忌、注意事项、剂型、规格6个方面的约束条件。以9种常见的口服降糖药作为待选药品,应用该模型选出的降糖类基本药物为格列吡嗪、格列齐特、二甲双胍和瑞格列奈。结论:本研究构建的基于背包理论的基本药物遴选模型较为科学、客观,有很强的实用性。更多还原

【Abstract】 OBJECTIVE:To provide reference for replenishing and perfecting essential medicine selection method in China.METHODS:According to the requirements of essential medicine selection,based on the actual situation,target function and restraint conditions for essential medicine selection could be determined by the knapsack theory and the essential medicine selection model could be built. The feasibility of established model was analyzed by an sample. RESULTS:The objective function of established model was Min∑C_jX_j,the minimum cost of all the selected essential medicines. Other constraints included covered range of disease,ADR,contraindications,attentions,dosage forms and specifications. Nine kinds of common oral hypoglycemic drugs were selected as candidate drugs,from which glipizide,gliclazide,metformin and repaglinide were chosen as the essential hypoglycemic medicines with the proposed model. CONCLUSIONS:Established essential medicine selection model based on knapsack theory is scientifical,objective and with strong practicality.更多还原